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All mouse models of bone marrow cancer with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | essential thrombocythemia | DccTg(H2-Kb-Jak2*V617F)1Shmd/Dcc+ | involves: C57BL/6 * DBA/2 | J:130189 | View | |||
| essential thrombocythemia |
Jak2tm1(JAK2)Argr/Jak2+ Tg(Mx1-cre)1Cgn/0 |
involves: 129S7/SvEvBrd * C57BL/6 * CBA | J:164539 | View | ||||
| juvenile myelomonocytic leukemia |
Nf1tm1Fcr/Nf1+ Ptentm1Hwu/Ptentm1Hwu Tg(Mx1-cre)1Cgn/0 |
B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu | J:232645 | View | ||||
| juvenile myelomonocytic leukemia |
Nf1tm1Par/Nf1tm1Par Tg(Mx1-cre)1Cgn/0 |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA | J:90973 | View | ||||
| juvenile myelomonocytic leukemia |
Ptpn11tm6Bgn/Ptpn11+ Tg(Mx1-cre)1Cgn/0 |
involves: 129S6/SvEvTac * C57BL/6 * CBA | J:148430 | View | ||||
| myelodysplastic syndrome |
Asxl1tm1.1Iaai/Asxl1tm1.1Iaai Tg(Mx1-cre)1Cgn/0 |
involves: 129S/SvEv * C57BL/6 * CBA | J:208092 | View | ||||
| myelodysplastic syndrome |
Asxl1tm1.1Iaai/Asxl1tm1.1Iaai Tg(VAV1-cre)1Graf/0 |
involves: 129S/SvEv * C57BL/6 | J:208092 | View | ||||
| myelodysplastic syndrome | Asxl1tm1.1Mjxu/Asxl1+ | involves: 129 * C57BL/6 | J:208085 | View | ||||
| myelodysplastic syndrome | Asxl1tm1.1Mjxu/Asxl1tm1.1Mjxu | involves: 129 * C57BL/6 | J:208085 | View | ||||
| myelodysplastic syndrome |
Sf3b1tm1.1Mdf/Sf3b1+ Tet2tm1.1Iaai/Tet2tm1.1Iaai Tg(Mx1-cre)1Cgn/? |
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J | J:234976 | View | ||||
| myelodysplastic syndrome | Sf3b1tm1Hko/Sf3b1+ | Not Specified | J:324276 | View | ||||
| myelodysplastic syndrome |
Srsf2tm1.1Oaw/Srsf2+ Tg(Mx1-cre)1Cgn/? |
B6.Cg-Tg(Mx1-cre)1Cgn Srsf2tm1.1Oaw | J:221404 | View | ||||
| myelodysplastic syndrome | Tg(Vav1-Asxl1*Y588X)#Fcy/0 | C57BL/6-Tg(Vav1-Asxl1*Y588X)#Fcy | J:257690 | View | ||||
| myelofibrosis | Jak2tm1.1Jlvl/Jak2tm1.1Jlvl | involves: 129S2/SvPas * C57BL/6 | J:163497 | View | ||||
| myelofibrosis | Tg(H2-Kb-Jak2*V617F)2Shmd/0 | involves: C57BL/6 * DBA/2 | J:130189 | View | ||||
| myeloproliferative neoplasm | Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo | C57BL/6J-Pdgfrbb2b2903Clo | J:175213 | View | ||||
| polycythemia vera | DccTg(H2-Kb-Jak2*V617F)1Shmd/Dcc+ | involves: C57BL/6 * DBA/2 | J:130189 | View | ||||
| polycythemia vera | Jak2tm1.1Jlvl/Jak2tm1.1Jlvl | involves: 129S2/SvPas * C57BL/6 | J:163497 | View | ||||
| polycythemia vera | Jak2tm1.2Ble/Jak2+ | involves: 129S6/SvEvTac * C57BL/6 * FVB/N | J:160883 | View | ||||
| polycythemia vera |
Jak2tm1.2Ble/Jak2+ Picalmtm1.1Tmae/Picalm+ Commd10Tg(Vav1-icre)A2Kio/Commd10+ |
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL | J:220728 | View | ||||
| polycythemia vera |
Jak2tm1Mohi/Jak2+ Tg(Mx1-cre)1Cgn/0 |
involves: C57BL/6 * CBA | J:183821 | View | ||||
| polycythemia vera |
Jak2tm1Mohi/Jak2tm1Mohi Tg(Mx1-cre)1Cgn/0 |
involves: C57BL/6 * CBA | J:183821 | View | ||||
| | essential thrombocythemia | Mybboo/Mybboo | involves: C57BL/6 | J:167270 | View | |||
| juvenile myelomonocytic leukemia | Flt3tm1Dgg/Flt3+ | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:126003 | View | ||||
| juvenile myelomonocytic leukemia | Flt3tm1Dgg/Flt3tm1Dgg | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:126003 | View | ||||
| juvenile myelomonocytic leukemia |
Krastm4Tyj/Kras+ Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ Tg(Flt3-cre)#Ccb/0 |
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 | J:247853 | View | ||||
| juvenile myelomonocytic leukemia |
Krastm4Tyj/Kras+ Tg(Mx1-cre)1Cgn/0 |
involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA | J:88163 | View | ||||
| juvenile myelomonocytic leukemia |
Krastm4Tyj/Kras+ Tg(Mx1-cre)1Cgn/0 |
involves: 129S4/SvJae * C57BL/6 * CBA | J:87429, J:115071 | View | ||||
| multiple myeloma | Tg(Igh-Maf)68Staka/0 | C57BL/6-Tg(Igh-Maf)68Staka | J:168074 | View | ||||
| multiple myeloma | Tg(Igh-Maf)524Staka/0 | involves: C57BL/6 * C57BL/6J * DBA/2 | J:168074 | View | ||||
| myelodysplastic syndrome |
Atg7tm1Tchi/Atg7tm1Tchi Commd10Tg(Vav1-icre)A2Kio/Commd10+ |
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj | J:176843 | View | ||||
| myelodysplastic syndrome |
Bap1tm1.1Geno/Bap1tm1.1Geno Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ |
involves: C57BL/6 * C57BL/6NTac | J:187380 | View | ||||
| myelodysplastic syndrome | Crebbptm1Dli/Crebbp+ | involves: 129S6/SvEvTac * C57BL/6 | J:191503 | View | ||||
| myelodysplastic syndrome | Egr1tm1Jmi/Egr1tm1Jmi | involves: 129 * C57BL/6 | J:123870 | View | ||||
| myelodysplastic syndrome | Gata1tm1Mym/Gata1+ | involves: 129P2/OlaHsd | J:88685 | View | ||||
| myelodysplastic syndrome | Macroh2a1tm1.1Oxbo/Macroh2a1tm1.1Oxbo | B6.Cg-Macroh2a1tm1.1Oxbo | J:293382 | View | ||||
| myelodysplastic syndrome |
Mybl2tm1.1Jof/Mybl2+ Tg(Zp3-cre)3Mrt/0 |
involves: 129S2/SvPas * C57BL/6 * FVB/N | J:196804 | View | ||||
| myelodysplastic syndrome | Npm1tm1Ppp/Npm1+ | involves: 129S1/Sv * C57BL/6 | J:101494 | View | ||||
| myelodysplastic syndrome | Polgtm1Prol/Polgtm1Prol | B6J.129S7-Polgtm1Prol | J:154187 | View | ||||
| myelodysplastic syndrome | Samd9ltm1Homy/Samd9l+ | involves: 129P2/OlaHsd | J:202604 | View | ||||
| myelodysplastic/myeloproliferative neoplasm | Dido1tm1Cmar/Dido1tm1Cmar | involves: 129S1/Sv * 129X1/SvJ | J:101201 | View | ||||
| myelofibrosis | Gata1tm2Sho/Gata1tm2Sho | involves: 129S4/SvJae * C57BL/6 * CD-1 | J:78348 | View | ||||
| myelofibrosis | Gata1tm2Sho/Y | involves: 129S4/SvJae * C57BL/6 * CD-1 | J:78348 | View | ||||
| myelofibrosis | Mybboo/Mybboo | involves: C57BL/6 | J:167270 | View | ||||
| myelofibrosis | Ncor2tm1Rev/Ncor2tm1Rev | involves: 129/Sv * C57BL/6 | J:202976 | View | ||||
| myeloproliferative neoplasm |
Jak2tm1.1Ble/Jak2+ Commd10Tg(Vav1-icre)A2Kio/Commd10+ |
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca | J:257910 | View | ||||
| myeloproliferative neoplasm | Tg(Vav1-Asxl1*Y588X)#Fcy/0 | C57BL/6-Tg(Vav1-Asxl1*Y588X)#Fcy | J:257690 | View | ||||
| | transient myeloproliferative syndrome |
Gata1tm1Mym/Gata1tm1Mym Tg(Gata1*)#Mym/0 |
involves: 129P2/OlaHsd * C57BL/6 * DBA/2J | J:158252 | View | |||
| transient myeloproliferative syndrome |
Gata1tm1Mym/Y Tg(Gata1*)#Mym/0 |
involves: 129P2/OlaHsd * C57BL/6 * DBA/2J | J:158252 | View | ||||
| Transgenes and Other Mutations | essential thrombocythemia |
Tg(JAK2*V617F)FF1Rsko/0 Commd10Tg(Vav1-icre)A2Kio/Commd10+ |
involves: C57BL/6 * C57BL/10 * CBA/Ca | J:134364 | View | |||
| essential thrombocythemia | Tg(Vav1-JAK2*V617F)AZjz/0 | involves: C57BL/6 * DBA/2 | J:135993 | View | ||||
| multiple myeloma | Tg(Cd4-NPM/ALK)N1Ingh/0 | either: (involves: BALB/c * Swiss Webster) or (involves: C57BL/6 * Swiss Webster) | J:82127 | View | ||||
| multiple myeloma | Tg(Igkv3-5*-MYC)24Plbe/0 | C57BL/6J-Tg(Igkv3-5*-MYC)DLoxP4Plbe/PlbeMmmh | J:131912 | View | ||||
| myelodysplastic syndrome | Tg(CMV-SALL4_iB)#Chai/? | Not Specified | J:115037 | View | ||||
| myelodysplastic syndrome | Tg(Vav1-NUP98/HOXD13)C1Apla/0 | FVB/N-Tg(Vav1-NUP98/HOXD13)C1Apla | J:107446 | View | ||||
| myelodysplastic syndrome | Tg(Vav1-NUP98/HOXD13)G2Apla/0 | C57BL/6-Tg(Vav1-NUP98/HOXD13)G2Apla | J:107446 | View | ||||
| myelofibrosis | Tg(Vav1-JAK2*V617F)AZjz/0 | involves: C57BL/6 * DBA/2 | J:135993 | View | ||||
| polycythemia vera |
Tg(JAK2*V617F)FF1Rsko/0 Tg(Mx1-cre)1Cgn/0 |
involves: C57BL/6 * CBA | J:134364 | View | ||||
| polycythemia vera | Tg(Vav1-JAK2*V617F)AZjz/0 | involves: C57BL/6 * DBA/2 | J:135993 | View | ||||
| Additional Complex Models | multiple myeloma |
Ightm1(Myc)Janz/Igh+ Tg(Emu-FGFR3)A5Wmk/0 |
involves: 129X1/SvJ * C57BL/6 * FVB/N | J:160845 | View | |||
| multiple myeloma |
Ightm1(Myc)Janz/Igh+ Tg(Emu-FGFR3)D3Wmk/0 |
involves: 129X1/SvJ * C57BL/6 * FVB/N | J:160845 | View | ||||
| myeloproliferative neoplasm |
Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+ Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+ |
involves: 129S4/SvJae * C57BL/6 | J:229031 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | essential thrombocythemia | Jak2tm1.1Jlvl/Jak2tm1.1Jlvl | involves: 129S2/SvPas * C57BL/6 | J:163497 | View | |||