Excel File Text File All mouse models of type 1 diabetes mellitus with phenotypic similarity to the human disease
        Disease Term Allelic Composition Genetic Background Reference Phenotypes
      type 1 diabetes mellitus Cd38tm1Lnd/Cd38tm1Lnd NOD.129P2(B6)-Cd38tm1Lnd/LtJ J:108097 View
type 1 diabetes mellitus Gad2tm1Miya/Gad2tm1Miya NOD.129P2-Gad2tm1Miya J:88785 View
type 1 diabetes mellitus H2g7/H2g7
Ins2tm1Jja/Ins2tm1Jja
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0		 involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD J:111874 View
type 1 diabetes mellitus Il1r1tm1Roml/Il1r1tm1Roml NOD.Cg-Il1r1tm1Roml J:87251 View
type 1 diabetes mellitus Ins1tm1Jja/Ins1tm1Jja
Tg(Ins2*Y16A)1Ell/0		 NOD.Cg-Ins1tm1Jja Tg(Ins2*Y16A)1Ell J:98583 View
type 1 diabetes mellitus Ins2Akita/Ins2Akita C.B6N-Ins2Akita J:198186 View
type 1 diabetes mellitus Ins2Akita/Ins2Akita
Itga1tm1Gdnr/Itga1tm1Gdnr		 C.Cg-Ins2Akita Itga1tm1Gdnr J:198186 View
type 1 diabetes mellitus Ins2tm1Jja/Ins2tm1Jja NOD.129S2-Ins2tm1Jja J:85309 View
type 1 diabetes mellitus Ptprn2tm1Aln/Ptprn2tm1Aln involves: 129S4/SvJae * C57BL/6N * NOD/LtJ J:81889 View
type 1 diabetes mellitus Tg(H2-Ea-Ins2)1Wehi/0 NOD/ShiLtJWehi-Tg(H2-Ea-Ins2)1Wehi J:100251 View
      type 1 diabetes mellitus Agertm1.1Hyam/Agertm1.1Hyam
Tg(Ins2-Nos2)40Okam/0		 involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2 J:116040 View
type 1 diabetes mellitus Cdk4tm1Bbd/Cdk4tm1Bbd involves: 129S1/Sv * 129X1/SvJ * ICR J:54534 View
type 1 diabetes mellitus E2f1tm1Meg/E2f1tm1Meg NOD.Cg-E2f1tm1Meg J:93708 View
type 1 diabetes mellitus Faslpr/Faslpr
Tg(Ins2-Fasl)24Ach/0		 NOD.Cg-Faslpr Tg(Ins2-Fasl)24Ach J:81416 View
type 1 diabetes mellitus Ifngtm1Ts/Ifngtm1Ts NOD.129S7(B6)-Ifngtm1Ts/DvsJ J:72818 View
type 1 diabetes mellitus Ifngtm1Ts/Ifngtm1Ts NOD.Cg-Ifngtm1Ts Prkdcscid J:72818 View
type 1 diabetes mellitus Ifngr2tm1Pbro/Ifngr2tm1Pbro NOD.129S1-Ifngr2tm1Pbro J:72818 View
type 1 diabetes mellitus Ighmtm1Cgn/Ighm+ NOD.129S2-Ighmtm1Cgn J:37287 View
type 1 diabetes mellitus Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V281)3Jwt/0		 NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt J:91865 View
type 1 diabetes mellitus Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-VB1-8/Igh-6m)1Mjsk/?		 NODCaj.Cg-Ighmtm1Cgn Tg(Igh-VB1-8/Igh-6m)1Mjsk/FswJ J:93190 View
type 1 diabetes mellitus Il4tm1Cgn/Il4tm1Cgn either: NOD.129-Il4tm1Cgn or (involves: 129 * NOD) J:85924 View
type 1 diabetes mellitus Il4tm1Cgn/Il4tm1Cgn
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0		 NOD.Cg-Il4tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi J:85924 View
type 1 diabetes mellitus Irak3tm1Flv/Irak3tm1Flv NOD.129S1(B6)-Irak3tm1Flv J:229884 View
type 1 diabetes mellitus Mbd2tm1Bh/Mbd2tm1Bh NOD.129P2(B6)-Mbd2tm1Bh J:323838 View
type 1 diabetes mellitus Pdx1tm1Cvw/Pdx1tm4Cvw
Tg(Ins2-cre)25Mgn/0		 involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA J:130389 View
type 1 diabetes mellitus Prf1tm1Clrk/Prf1tm1Clrk involves: 129S7/SvEvBrd * BALB/c * NOD J:64051 View
type 1 diabetes mellitus Prf1tm1Clrk/Prf1tm1Clrk
Tg(INS-Il10)#Sar/0		 involves: 129S7/SvEvBrd * BALB/c * NOD J:64051 View
type 1 diabetes mellitus Selltm1Flv/Sell+ involves: C57BL/6 * NOD J:88974 View
type 1 diabetes mellitus Selltm1Flv/Sell+ NOD.Cg-Selltm1Flv J:88974 View
type 1 diabetes mellitus Selltm1Flv/Selltm1Flv involves: C57BL/6 * NOD J:88974 View
type 1 diabetes mellitus Selltm1Flv/Selltm1Flv NOD.Cg-Selltm1Flv J:88974 View
type 1 diabetes mellitus Senp1tm1Wami/Senp1tm1Wami
Tg(Fabp4-cre)#Abel/0		 B6.Cg-Senp1tm1Wami Tg(Fabp4-cre)#Abel J:228009 View
type 1 diabetes mellitus Stat4tm1Gru/Stat4+ NOD.129S2-Stat4tm1Gru J:90600 View
type 1 diabetes mellitus Stat4tm1Gru/Stat4tm1Gru C.129S2-Stat4tm1Gru J:106340 View
type 1 diabetes mellitus Stat4tm1Gru/Stat4tm1Gru
Tg(Ins2-GP)34-20Olds/0		 involves: 129S2/SvPas * BALB/c * C57BL/6 J:107047 View
type 1 diabetes mellitus Stat4tm1Gru/Stat4tm1Gru
Tg(Ins2-NP)25-3Olds/0		 involves: 129S2/SvPas * BALB/c * C57BL/6 J:107047 View
type 1 diabetes mellitus Tg(H2-Ea-G6pc2)69Tkay/? NOD-Tg(H2-Ea-G6pc2)69Tkay J:117352 View
type 1 diabetes mellitus Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0		 NOD.B6-Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt J:91865 View
type 1 diabetes mellitus Tg(Igh-6/Igh-V281)3Jwt/0 NOD.B6-Tg(Igh-6/Igh-V281)3Jwt J:91865 View
type 1 diabetes mellitus Tg(Ins2-Fas*I246N)1Ach/0
Tg(Ins2-Fasl)24Ach/0		 NOD-Tg(Ins2-Fas*I246N)1Ach Tg(Ins2-Fasl)24Ach J:81416 View
type 1 diabetes mellitus Tg(Ins2-Fasl)24Ach/0 NOD-Tg(Ins2-Fasl)24Ach/J J:78679 View
type 1 diabetes mellitus Tg(Ins2-Nos2)31Okam/0 involves: C57BL/6 * CD-1 * DBA/2 J:45520 View
type 1 diabetes mellitus Tg(Ins2-Nos2)40Okam/0 involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2 J:116040 View
type 1 diabetes mellitus Tg(Ins2-Nos2)40Okam/0 involves: C57BL/6 * CD-1 * DBA/2 J:4552 View
type 1 diabetes mellitus Tg(Ins2-Nos2)40Okam/0
Tg(Kdr-AGER)102Hyam/0		 involves: C57BL/6J * CBA/J * CD-1 * DBA/2 J:70495 View
type 1 diabetes mellitus Tnfsf4tm1Shr/Tnfsf4tm1Shr NOD.129S4-Tnfsf4tm1Shr J:86926 View
type 1 diabetes mellitus 2 Apobtm2Sgy/Apobtm2Sgy
Ldlrtm1Her/Ldlrtm1Her
Tg(Ins-Igf2)1Fbos/?		 involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL J:227165 View
type 1 diabetes mellitus 2 Tg(Ins-Igf2)1Fbos/0 involves: C57BL/6 * C57BLKs/J * SJL J:141527 View
type 1 diabetes mellitus 2 Tg(Ins-Igf2)1Fbos/0 involves: C57BL/6 * SJL J:141527 View
type 1 diabetes mellitus 7 Neurod1tm1Mjts/Neurod1tm1Mjts involves: 129S7/SvEvBrd * C57BL/6 J:43010 View
      type 1 diabetes mellitus Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr		 involves: 129S4/SvJae * NOD J:61905 View
type 1 diabetes mellitus H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0		 involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA * SJL J:68641 View
type 1 diabetes mellitus H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(Ins2-CD80)3B7Flv/0		 B6.Cg-H2-Ab1b-tm1Gru Tg(HLA-DQA1,HLA-DQB1)1Dv Tg(Ins2-CD80)3B7Flv J:59245 View
type 1 diabetes mellitus H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0		 involves: 129S2/SvPas * C57BL/6 * CBA * SJL J:68641 View
type 1 diabetes mellitus Tg(Ins1-Cd80)378Psoh/0
Tg(Ins2-GP)#Psoh/0
Tg(TcrLCMV)327Sdz/0		 involves: C57BL/6 * DBA/2 * FVB/N J:209714 View
Transgenes and
Other Mutations		     type 1 diabetes mellitus B2mtm1Unc/B2mtm1Unc
Tg(HLA-A/H2-D/B2M)1Dvs/0		 NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs J:121685 View
type 1 diabetes mellitus Cd4tm1Knw/Cd4tm1Knw
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0		 NOD.Cg-Cd4tm1Knw Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:93553 View
type 1 diabetes mellitus Fastm1Vbo/Fastm1Vbo
Tg(Ins2-cre)25Mgn/0
Tg(Ins2-HA)165Bri/0
Tg(Tcra/Tcrb)1Vbo/0		 Not Specified J:85985 View
type 1 diabetes mellitus H2g7/H2g7
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0		 involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD J:111874 View
type 1 diabetes mellitus H2g7/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0		 involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD J:111874 View
type 1 diabetes mellitus Prkdcscid/Prkdcscid
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0		 NOD.Cg-Prkdcscid Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:93553 View
type 1 diabetes mellitus Rag1tm1Mom/Rag1tm1Mom
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0		 NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs/Dvs J:94192 View
type 1 diabetes mellitus Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0		 involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD J:111874 View
type 1 diabetes mellitus Tg(Cryaa-TAg,Ins2-CALM1)26Ove/0 FVB(Cg)-Tg(Cryaa-Tag,Ins2-CALM1)26Ove/PneJ J:97926 View
type 1 diabetes mellitus Tg(Cryaa-TAg,Ins2-CALM1)26Ove/0 FVB-Tg(Cryaa-TAg,Ins2-CALM1)26Ove J:94602 View
type 1 diabetes mellitus Tg(H2-Ead)12Lt/0 NOD/ShiLt-Tg(H2-Ead)12Lt J:36435 View
type 1 diabetes mellitus Tg(HLA-A/H2-D/B2M)1Dvs/0 NOD/ShiLtDvs-Tg(HLA-A/H2-D/B2M)1Dvs J:121685 View
type 1 diabetes mellitus Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg NOD.B6-Tg(IghelMD4)4Ccg/DvsJ J:80859 View
type 1 diabetes mellitus Tg(Ins1-Cat,Tyr)25Pne/0 involves: FVB J:59725 View
type 1 diabetes mellitus Tg(Ins1-Cat,Tyr)25Pne/0 NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne J:108415 View
type 1 diabetes mellitus Tg(Ins2*Y16A)3Ell/0 NOD-Tg(Ins2*Y16A)3Ell J:98583 View
type 1 diabetes mellitus Tg(Ins2-CD80)3B7Flv/? involves: C57BL/6 * CBA/Ca * NOD/Caj J:26618 View
type 1 diabetes mellitus Tg(Ins2-GP)34-20Olds/0 involves: BALB/c * C57BL/6 J:81287 View
type 1 diabetes mellitus Tg(Ins2-HBEGF)5Rin/? C57BL/6-Tg(Ins2-HBEGF)5Rin J:204420 View
type 1 diabetes mellitus Tg(Ins2-NP)25-3Olds/0 involves: BALB/c * C57BL/6 J:81284 View
type 1 diabetes mellitus Tg(INS-MT2A,Tyr)1Pne/0 FVB-Tg(INS-MT2A,Tyr)1Pne J:100251 View
type 1 diabetes mellitus Tg(INS-MT2A,Tyr)1Pne/0 NOD.FVB-Tg(INS-MT2A,Tyr)1Pne J:108415 View
type 1 diabetes mellitus Tg(INS-SOD2)3Pne/0 NOD.FVB-Tg(INS-SOD2)3Pne J:108415 View
type 1 diabetes mellitus Tg(TcraAI4)1Dvs/0 NOD-Tg(TcraAI4)1Dvs J:93553 View
type 1 diabetes mellitus Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0		 NOD-Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:93553 View
type 1 diabetes mellitus Tg(TcraTcrbNY8.3)1Pesa/? involves: C57BL/6 * NOD * SJL J:44202 View
Additional
Complex
Models		     type 1 diabetes mellitus Casp1tm1Sesh/Casp1tm1Sesh
Casp4del/Casp4del		 NOD.129S2(B6)-Casp1tm1Sesh Casp4del/LtJ J:87250 View
type 1 diabetes mellitus Prkdcscid/Prkdcscid
Tg(INS-HBEGF*L148S*P149T)70Rin/0		 C.BKa-Prkdcscid Tg(INS-HBEGF*L148S*P149T)70Rin J:204420 View

       
No similarity to the expected human disease phenotype was found.
        Disease Term Allelic Composition Genetic Background Reference Phenotypes
NOT Models      type 1 diabetes mellitus B2mtm1Jae/B2mtm1Jae
Tg(B2m)1Rms/0
Tg(INS-cre)2Rms/0		 involves: 129S2/SvPas * NOD J:83635 View
type 1 diabetes mellitus B2mtm1Unc/B2mtm1Unc NOD.129P2-B2mtm1Unc J:17000 View
type 1 diabetes mellitus B2mtm1Unc/B2mtm1Unc
Ciitatm1Ccum/Ciitatm1Ccum		 NOD.Cg-B2mtm1Unc Ciitatm1Ccum J:107051 View
type 1 diabetes mellitus B2mtm1Unc/B2mtm1Unc
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0		 NOD.Cg-B2mtm1Unc Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs J:93553 View
type 1 diabetes mellitus Casp3tm1Mak/Casp3tm1Mak B6.129P2-Casp3tm1Mak J:97650 View
type 1 diabetes mellitus Cd4tm1Knw/Cd4tm1Knw NOD.Cg-Cd4tm1Knw J:93553 View
type 1 diabetes mellitus Ciitatm1Ccum/Ciitatm1Ccum NOD.129S2(B6)-Ciitatm1Ccum J:106081 View
type 1 diabetes mellitus Ctnna2tm1Mta/Ctnna2tm1Mta Not Specified J:83635 View
type 1 diabetes mellitus Faslpr/Faslpr NOD.MRL(B6)-Faslpr J:64051 View
type 1 diabetes mellitus H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell		 NOD.Cg-H2-Ab1b-tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell J:87013 View
type 1 diabetes mellitus Icam1tm1Jcgr/Icam1tm1Jcgr
Tg(INS-Il10)#Sar/0		 NOD.Cg-Icam1tm1Jcgr Tg(INS-Il10)#Sar J:98583 View
type 1 diabetes mellitus Ighmtm1Cgn/Ighmtm1Cgn NOD.129S2-Ighmtm1Cgn J:37287 View
type 1 diabetes mellitus Ighmtm1Cgn/Ighmtm1Cgn NOD.129S2-Ighmtm1Cgn/DvsJ J:80859 View
type 1 diabetes mellitus Ighmtm1Cgn/Ighmtm1Cgn
Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg		 NOD.Cg-Ighmtm1Cgn Tg(IghelMD4)4Ccg/DvsJ J:80859 View
type 1 diabetes mellitus Ins1tm1Jja/Ins1tm1Jja NOD.129S2-Ins1tm1Jja J:85309 View
type 1 diabetes mellitus Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)1Ell/0		 NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)1Ell J:98583 View
type 1 diabetes mellitus Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)3Ell/0		 NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)3Ell J:98583 View
type 1 diabetes mellitus Parp1tm1Hsmm/Parp1tm1Hsmm involves: 129S4/SvJae J:53360 View
type 1 diabetes mellitus Stat4tm1Gru/Stat4tm1Gru NOD.129S2-Stat4tm1Gru J:90600 View
type 1 diabetes mellitus Tg(H2-Ead)5Lt/0 NOD/ShiLt-Tg(H2-Ead)5Lt J:36435 View
type 1 diabetes mellitus Tg(TcrbAI4)1Dvs/0 NOD-Tg(TcrbAI4)1Dvs J:93553 View
type 1 diabetes mellitus Tlr2tm1Aki/Tlr2tm1Aki NOD.129P2-Tlr2tm1Aki J:124334 View
type 1 diabetes mellitus 2 Hk2tm1Laak/Hk2+ involves: 129P2/OlaHsd * BALB/c * DBA/2 J:56644 View