Symbol Name ID |
Disc1
disrupted in schizophrenia 1 MGI:2447658 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Negativism |
Lack of spontaneous play |
Impaired ability to form peer relationships |
Autism |
Autism with high cognitive abilities |
Inflexible adherence to routines |
Motor stereotypy |
Restrictive behavior |
Disease(s) Associated with DISC1 | ||||||||
Asperger syndrome | ||||||||
autistic disorder | ||||||||
schizophrenia |
Mouse Phenotypes | behavior/neurological phenotype |
abnormal learning/memory/conditioning |
impaired passive avoidance behavior |
enhanced contextual conditioning behavior |
abnormal latent inhibition of conditioning behavior |
decreased exploration in new environment |
increased exploration in new environment |
abnormal spatial learning |
abnormal spatial working memory |
abnormal liquid preference |
behavioral despair |
decreased anxiety-related response |
increased anxiety-related response |
increased thigmotaxis |
abnormal response to novel object |
abnormal impulsive behavior control |
decreased startle reflex |
decreased vertical activity |
increased locomotor activity |
hyperactivity |
induced hyperactivity |
abnormal social/conspecific interaction behavior |
abnormal social investigation |
social withdrawal |
decreased vocalization |
|
Availability | Mouse Genotype | |||||||||||||||||||||||||
Disc1del/Disc1del | ||||||||||||||||||||||||||
Disc1em1(IMPC)Mbp/Disc1em1(IMPC)Mbp | ||||||||||||||||||||||||||
Disc1m1H/Disc1m1H | * | |||||||||||||||||||||||||
Disc1Rgsc1390/Disc1Rgsc1390 | * | |||||||||||||||||||||||||
Disc1Rgsc1393/Disc1Rgsc1393 | * | |||||||||||||||||||||||||
Disc1tm1Kara/Disc1tm1Kara | ||||||||||||||||||||||||||
Disc1tm1Kozo/Disc1tm1Kozo | * | |||||||||||||||||||||||||
Disc1Rgsc1390/Disc1+ | * | |||||||||||||||||||||||||
Disc1Rgsc1390/Disc1Rgsc1393 | ||||||||||||||||||||||||||
Disc1Rgsc1393/Disc1+ | ||||||||||||||||||||||||||
Disc1tm1Kara/Disc1+ | ||||||||||||||||||||||||||
Tg(Camk2a-ESR1/Disc1*)2698.1Sva/0 | ||||||||||||||||||||||||||
Tg(Disc1/EGFP)M19Sshe/0 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/02/2024 MGI 6.24 |
|
|