Symbol Name ID |
Syngap1
synaptic Ras GTPase activating protein 1 homolog (rat) MGI:3039785 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Autistic behavior |
Disease(s) Associated with SYNGAP1 | |
autosomal dominant intellectual developmental disorder 5 |
Mouse Phenotypes | behavior/neurological phenotype |
increased susceptibility to pharmacologically induced seizures |
impaired cued conditioning behavior |
abnormal discrimination learning |
abnormal spatial learning |
abnormal spatial working memory |
abnormal suckling behavior |
decreased anxiety-related response |
abnormal motor capabilities/coordination/movement |
increased startle reflex |
tremors |
weakness |
increased locomotor activity |
hyperactivity |
bradykinesia |
increased horizontal stereotypic behavior |
abnormal social/conspecific interaction behavior |
social withdrawal |
audiogenic seizures |
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Availability | Mouse Genotype | |||||||||||||||||||
Syngap1tm1.1Mabk/Syngap1tm1.1Mabk | ||||||||||||||||||||
Syngap1tm1Rlh/Syngap1tm1Rlh | ||||||||||||||||||||
Syngap1tm1Grnt/Syngap1+ | ||||||||||||||||||||
Syngap1tm1Rlh/Syngap1+ | * |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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