Symbol
Name
ID

Mecp2
methyl CpG binding protein 2
MGI:99918

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Anorexia

Feeding difficulties

Feeding difficulties in infancy

Gastrostomy tube feeding in infancy

Poor suck

Emotional lability

Aggressive behavior

Hyperactivity

Inflexible adherence to routines

Inappropriate crying

Lack of spontaneous play

Reduced social responsiveness

Impaired ability to form peer relationships

Autistic behavior

Autism

Bipolar affective disorder

Abnormal fear-induced behavior

Motor stereotypy

Bruxism

Tongue thrusting

Stereotypical hand wringing

Repetitive compulsive behavior

Restrictive behavior

Disease(s) Associated with MECP2

autistic disorder

Rett syndrome

severe congenital encephalopathy due to MECP2 mutation

syndromic X-linked intellectual disability Lubs type

X-linked intellectual disability-psychosis-macroorchidism syndrome

Mouse Phenotypes

behavior/neurological phenotype

abnormal behavior

lethargy

increased susceptibility to pharmacologically induced seizures

abnormal associative learning

abnormal contextual conditioning behavior

impaired contextual conditioning behavior

abnormal cued conditioning behavior

impaired cued conditioning behavior

abnormal motor learning

impaired long-term object recognition memory

abnormal spatial learning

abnormal spatial working memory

abnormal fear/anxiety-related behavior

decreased anxiety-related response

decreased thigmotaxis

increased anxiety-related response

increased fear-related response

increased grooming behavior

abnormal motor capabilities/coordination/movement

abnormal pilomotor reflex

decreased startle reflex

limb grasping

tremors

abnormal motor coordination/balance

ataxia

impaired coordination

decreased grip strength

abnormal locomotor behavior

abnormal locomotor activation

akinesia

abnormal locomotor coordination

abnormal gait

short stride length

decreased vertical activity

increased vertical activity

decreased locomotor activity

hyperactivity

stereotypic behavior

increased stereotypic behavior

abnormal touch/ nociception

increased thermal nociceptive threshold

abnormal nest building behavior

abnormal social investigation

seizures

environmentally induced seizures

tonic-clonic seizures

sporadic seizures

Availability

Mouse Genotype

Mecp2^tm1.1Bird/Mecp2^tm1.1Bird

Mecp2^tm1.1Jtc/Mecp2^tm1.1Jtc

Mecp2^tm1.1Vnar/Mecp2^tm1.1Vnar

Mecp2^tm1.1Bird/Mecp2⁺

Mecp2^tm1.1Dhy/Mecp2⁺

Mecp2^tm1.1Irsf/Mecp2⁺

Mecp2^tm1.1Jae/Mecp2⁺

Mecp2^tm1.1Joez/Mecp2⁺

Mecp2^tm1.1Jtc/Mecp2⁺

Mecp2^tm1Hzo/Mecp2⁺

Mecp2^tm1Nlnd/Mecp2⁺

Mecp2^tm1Pplt/Mecp2⁺

Mecp2^tm1Vnar/Mecp2⁺

Mecp2^tm2Bird/Mecp2⁺

Mecp2^tm4.1Bird/Mecp2⁺

Mecp2^tm5.1Bird/Mecp2⁺

Mecp2^tm6.1Bird/Mecp2⁺

Mecp2^em1Jlzn/Y

Mecp2^tm1.1Bird/Y

Mecp2^tm1.1Dhy/Y

Mecp2^tm1.1Irsf/Y

Mecp2^tm1.1Jae/Y

Mecp2^tm1.1Joez/Y

Mecp2^tm1.1Jtc/Y

Mecp2^tm1Bird/Y

Mecp2^tm1Hzo/Y

Mecp2^tm1Jae/Y

Mecp2^tm1Jchr/Y

Mecp2^tm1Nlnd/Y

Mecp2^tm1Pplt/Y

Mecp2^tm1Vnar/Y

Mecp2^tm2.1Jae/Y

Mecp2^tm2.1Meg/Y

Mecp2^tm2Bird/Y

Mecp2^tm3.1Bird/Y

Mecp2^tm3.1Jae/Y

Mecp2^tm3Meg/Y

Mecp2^tm4.1Bird/Y

Mecp2^tm5.1Bird/Y

Mecp2^tm6.1Bird/Y

Mecp2^tm1Pplt/0

Mecp2^tm1Jae/Y
Chat^tm2(cre)Lowl/Chat⁺ (conditional)

Chat^tm2(cre)Lowl/Chat⁺
Mecp2^tm2Bird/Y (conditional)

Mecp2^tm1Jae/Mecp2⁺
Tg(Nes-cre)1Atp/0 (conditional)

Mecp2^tm2Bird/Mecp2⁺
Tg(CAG-cre/Esr1*)5Amc/? (conditional)

Mecp2^tm1Bird/Y
Pvalb^{tm1.1(cre)Aibs}/Pvalb⁺ (conditional)

Mecp2^tm1Bird/Y
Sst^{tm2.1(cre)Zjh}/Sst⁺ (conditional)

Mecp2^tm1Bird/Y
Tg(Nes-cre)1Kln/0 (conditional)

Mecp2^tm1Bird/Y
Tg(dlx5a-cre)1Mekk/0 (conditional)

Mecp2^tm1Bird/Y
Tg(Slc32a1-cre)2.1Hzo/0 (conditional)

Mecp2^tm1Jae/Y
Tg(Nes-cre)1Atp/0 (conditional)

Mecp2^tm1Jae/Y
Tg(Camk2a-cre)93Kln/0 (conditional)

Mecp2^tm1Jae/Y
Tg(Myh6-cre)2182Mds/0 (conditional)

Mecp2^tm2Bird/Y
Tg(CAG-cre/Esr1*)5Amc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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