Symbol
Name
ID

Gata5
GATA binding protein 5
MGI:109497

Phenotype annotations related to cardiovascular system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Left atrial enlargement

Atrial septal defect

Ventricular septal defect

Perimembranous ventricular septal defect

Atrioventricular canal defect

Abnormal left ventricular outflow tract morphology

Left ventricular hypertrophy

Right ventricular dilatation

Tetralogy of Fallot

Bicuspid aortic valve

Aortic valve calcification

Hypoplastic left heart

Ascending aortic dissection

Aortic arch aneurysm

Thoracic aorta calcification

Coarctation of aorta

Pulmonary artery stenosis

Patent ductus arteriosus

Stroke

Reduced left ventricular ejection fraction

Elevated left ventricular end-diastolic diameter

Heart murmur

Aortic regurgitation

Aortic valve stenosis

Tricuspid regurgitation

Pulmonic stenosis

Hypertension

Prolonged P wave

Prolonged PR interval

Prolonged QRS complex

Prolonged QTc interval

ST segment elevation

Sinus bradycardia

Bradycardia

Sudden cardiac death

Palpitations

Atrial fibrillation

Paroxysmal atrial fibrillation

Permanent atrial fibrillation

Atrial flutter

Premature atrial contractions

Supraventricular tachycardia

Myocardial infarction

Syncope

Disease(s) Associated with GATA5

bicuspid aortic valve disease

familial atrial fibrillation

tetralogy of Fallot

ventricular septal defect

Mouse Phenotypes

cardiovascular system phenotype

abnormal aorta bulb morphology

aorta stenosis

perivascular fibrosis

decreased myocardial fiber number

increased myocardial fiber size

myocardial trabeculae hypoplasia

abnormal heart development

decreased fetal cardiomyocyte number

increased heart right atrium size

thick interventricular septum

enlarged heart

abnormal aortic valve cusp morphology

bicuspid aortic valve

abnormal heart left ventricle morphology

increased heart left ventricle weight

abnormal heart right ventricle morphology

thin ventricular wall

abnormal blood circulation

increased heart ventricle muscle contractility

hypertension

salt-sensitive hypertension

increased systemic arterial diastolic blood pressure

increased systemic arterial systolic blood pressure

abnormal vasodilation

Availability

Mouse Genotype

Gata5^tm1.2Nemr/Gata5^tm1.2Nemr

Gata5^tm1.1Nemr/Gata5^tm1.1Nemr
Tg(Tek-cre)1Ywa/0 (conditional)

Gata5^tm1.1Nemr/Gata5^tm1.1Nemr
Tg(Tagln-cre)1Her/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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