Symbol Name ID |
Jag1
jagged 1 MGI:1095416 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Atrial septal defect |
Ventricular septal defect |
Tetralogy of Fallot |
Coarctation of aorta |
Peripheral pulmonary artery stenosis |
Renal artery stenosis |
Stroke |
Pulmonic stenosis |
Hypertension |
Telangiectasia of the skin |
Disease(s) Associated with JAG1 | ||||||||||
Alagille syndrome | ||||||||||
tetralogy of Fallot |
Mouse Phenotypes | cardiovascular system phenotype |
abnormal blood vessel morphology |
abnormal pulmonary trunk morphology |
abnormal aorta morphology |
retroesophageal right subclavian artery |
abnormal retina vasculature morphology |
abnormal liver vasculature morphology |
abnormal vascular development |
abnormal angiogenesis |
patent ductus arteriosus |
abnormal vascular branching morphogenesis |
decreased angiogenesis |
abnormal vitelline vasculature morphology |
abnormal vascular smooth muscle morphology |
heart right ventricle hypertrophy |
abnormal cardiac outflow tract development |
abnormal heart morphology |
abnormal coronary vessel morphology |
overriding aortic valve |
increased heart right atrium size |
atrial septal defect |
ventricular septal defect |
abnormal heart valve morphology |
calcified aortic valve |
pulmonary valve stenosis |
thick heart valve cusps |
increased heart right ventricle size |
increased heart right ventricle wall thickness |
pericardial edema |
distended pericardium |
enlarged pericardium |
dilated heart |
hemorrhage |
intracranial hemorrhage |
liver hemorrhage |
pulmonary valve regurgitation |
increased systemic arterial systolic blood pressure |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||
Jag1Mhdahtu/Jag1Mhdahtu | ||||||||||||||||||||||||||||||||||||||
Jag1Ndr/Jag1Ndr | ||||||||||||||||||||||||||||||||||||||
Jag1Slalom/Jag1Slalom | ||||||||||||||||||||||||||||||||||||||
Jag1tm1Grid/Jag1tm1Grid | ||||||||||||||||||||||||||||||||||||||
Jag1tm2.1Grid/Jag1tm2.1Grid | ||||||||||||||||||||||||||||||||||||||
Jag1Mhdahtu/Jag1Slalom | ||||||||||||||||||||||||||||||||||||||
Jag1tm1Frad/Jag1tm1Frad Tg(Tagln-cre)1Her/0 (conditional) |
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Jag1tm1Frad/Jag1tm1Frad Tg(Cdh5-cre)7Mlia/0 (conditional) |
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Jag1tm1Jlew/Jag1tm1Jlew Tg(Tie1-cre)9Ref/0 (conditional) |
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Jag1tm1Jlew/Jag1tm1Jlew Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 (conditional) |
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Jag1tm2Grid/Jag1tm2Grid Tg(Tek-cre)12Flv/0 (conditional) |
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Jag1tm2Grid/Jag1tm2Grid H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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Jag1tm1Grid/Jag1tm2Grid Tg(Tagln-cre)1Her/0 (conditional) |
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Jag1tm1Jlew/Jag1tm1Grid Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 (conditional) |
* |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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