Symbol Name ID |
Mre11a
MRE11A homolog A, double strand break repair nuclease MGI:1100512 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Increased sensitivity to ionizing radiation |
Disease(s) Associated with MRE11 | |
ataxia-telangiectasia-like disorder-1 |
Mouse Phenotypes | cellular phenotype |
abnormal cell cycle checkpoint function |
increased mitotic index |
decreased cellular sensitivity to ionizing radiation |
increased cellular sensitivity to ionizing radiation |
decreased cell proliferation |
abnormal DNA repair |
chromosomal instability |
chromosome breakage |
induced chromosome breakage |
spontaneous chromosome breakage |
maternal effect |
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Availability | Mouse Genotype | ||||||||||||
Mre11atm1.1Rchd/Mre11atm1.1Rchd | |||||||||||||
Mre11atm1Jpt/Mre11atm1Jpt | |||||||||||||
Mre11atm1Dof/Mre11atm2.1Dof (conditional) | * | ||||||||||||
Mre11atm2.1Dof/Mre11atm2.2Dof (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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