Symbol Name ID |
Pdx1
pancreatic and duodenal homeobox 1 MGI:102851 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Neonatal insulin-dependent diabetes mellitus |
Maturity-onset diabetes of the young |
Type II diabetes mellitus |
Pancreatic aplasia |
Pancreatic hypoplasia |
Exocrine pancreatic insufficiency |
Disease(s) Associated with PDX1 | ||||||
maturity-onset diabetes of the young type 4 | ||||||
pancreatic agenesis | ||||||
type 2 diabetes mellitus |
Mouse Phenotypes | abnormal pancreatic islet cell apoptosis |
abnormal pancreatic beta cell apoptosis |
increased pancreatic beta cell apoptosis |
abnormal pancreatic beta cell differentiation |
decreased pancreatic beta cell proliferation |
increased pancreatic alpha cell proliferation |
abnormal stomach enteroendocrine cell morphology |
abnormal pancreatic acinar cell morphology |
abnormal pancreatic duct morphology |
absent Brunner's glands |
exocrine pancreatic insufficiency |
endocrine/exocrine gland phenotype |
abnormal bile duct development |
abnormal pancreatic islet morphology |
abnormal PP cell morphology |
increased PP cell number |
decreased pancreatic alpha cell mass |
increased pancreatic alpha cell number |
decreased pancreatic beta cell mass |
decreased pancreatic beta cell number |
abnormal pancreatic delta cell morphology |
increased pancreatic delta cell number |
abnormal pancreatic epsilon cell morphology |
decreased pancreatic islet number |
abnormal pancreatic islet size |
small pancreatic islets |
pancreatic islet hypoplasia |
disorganized pancreatic islets |
abnormal pancreas development |
abnormal pancreas morphology |
decreased pancreas weight |
small pancreas |
pancreas hypoplasia |
absent pancreas |
increased glucagon secretion |
abnormal pancreatic beta cell physiology |
decreased amylin secretion |
decreased insulin secretion |
abnormal pancreatic endocrine progenitor cell physiology |
pancreas inflammation |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||
Pdx1tm1.1Stof/Pdx1tm1.1Stof | * | ||||||||||||||||||||||||||||||||||||||||
Pdx1tm1Cvw/Pdx1tm1Cvw | |||||||||||||||||||||||||||||||||||||||||
Pdx1tm1Ted/Pdx1tm1Ted | |||||||||||||||||||||||||||||||||||||||||
Pdx1tm2Cvw/Pdx1tm2Cvw | |||||||||||||||||||||||||||||||||||||||||
Pdx1tm3Cvw/Pdx1tm3Cvw | |||||||||||||||||||||||||||||||||||||||||
Pdx1tm1.1Stof/Pdx1+ | |||||||||||||||||||||||||||||||||||||||||
Pdx1tm1Cvw/Pdx1+ | * | ||||||||||||||||||||||||||||||||||||||||
Pdx1tm1Cvw/Pdx1tm1.1Stof | |||||||||||||||||||||||||||||||||||||||||
Pdx1tm1Ted/Pdx1+ | |||||||||||||||||||||||||||||||||||||||||
Pdx1tm2Cvw/Pdx1+ | |||||||||||||||||||||||||||||||||||||||||
Pdx1tm2Cvw/Pdx1tm3Cvw | |||||||||||||||||||||||||||||||||||||||||
Pdx1tm3Cvw/Pdx1+ | |||||||||||||||||||||||||||||||||||||||||
Pdx1tm1Heed/Pdx1tm1Heed Tg(Ins2-cre)1Heed/0 (conditional) |
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Pdx1tm1Cvw/Pdx1tm4Cvw Tg(Ins2-cre)25Mgn/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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