Symbol
Name
ID

Prkar1a
protein kinase, cAMP dependent regulatory, type I, alpha
MGI:104878

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes

Diabetes mellitus

Elevated circulating calcitonin concentration

Elevated circulating parathyroid hormone level

Neoplasm of the pancreas

Elevated circulating growth hormone concentration

Increased circulating insulin-like growth factor 1 concentration

Elevated circulating thyroid-stimulating hormone concentration

Increased circulating cortisol level

Pigmented micronodular adrenocortical disease

Decreased growth hormone responses to growth hormone-releasing hormone challenge

Increased circulating prolactin concentration

Pituitary adenoma

Pituitary growth hormone cell adenoma

Euthyroid multinodular goiter

Thyroid carcinoma

Follicular thyroid carcinoma

Papillary thyroid carcinoma

Thyroid follicular hyperplasia

Congenital hypothyroidism

Pheochromocytoma

Precocious puberty

Hypogonadism

Disease(s) Associated with PRKAR1A

acrodysostosis

Carney complex

Mouse Phenotypes

increased adrenal gland apoptosis

retention of the adrenal gland x-zone

abnormal adrenal cortex morphology

decreased adrenal gland zona fasciculata size

disorganized adrenal gland zona fasciculata

abnormal adrenal gland zona glomerulosa morphology

adrenal cortical hyperplasia

abnormal thyroid gland morphology

enlarged thyroid gland

increased pituitary gland tumor incidence

increased thyroid tumor incidence

increased thyroid carcinoma incidence

abnormal adrenal gland physiology

increased activity of thyroid gland

Availability

Mouse Genotype

Prkar1a^tm1.1Lsk/Prkar1a⁺

Prkar1a^tm1.2Lsk/Prkar1a^tm1.2Lsk
Tg(Ghrhr-cre)3242Lsk/0 (conditional)

Prkar1a^tm1.2Lsk/Prkar1a^tm1.2Lsk
Tg(TPO-cre)1Shk/0 (conditional)

Prkar1a^tm1Lsk/Prkar1a^tm1Lsk
Tg(Akr1b7-cre)1Anm/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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