Symbol Name ID |
Irs2
insulin receptor substrate 2 MGI:109334 |
Darker colors indicate more annotations |
Human Phenotypes | Type II diabetes mellitus |
Disease(s) Associated with IRS2 | |
type 2 diabetes mellitus |
Mouse Phenotypes | decreased granulosa cell proliferation |
abnormal pancreatic beta cell morphology |
decreased pancreatic beta cell mass |
increased pancreatic beta cell mass |
decreased pancreatic beta cell number |
small pancreatic islets |
decreased gonadotroph cell number |
small pituitary gland |
small pituitary intermediate lobe |
abnormal corpus luteum morphology |
absent corpus luteum |
abnormal ovarian follicle morphology |
absent mature ovarian follicles |
decreased primary ovarian follicle number |
decreased tertiary ovarian follicle number |
increased atretic ovarian follicle number |
abnormal ovarian folliculogenesis |
impaired ovarian folliculogenesis |
polyovular ovarian follicle |
small ovary |
increased insulin secretion |
|
Availability | Mouse Genotype | |||||||||||||||||||||
Irs2M1Btlr/Irs2M1Btlr | ||||||||||||||||||||||
Irs2tm1.1With/Irs2tm1.1With | ||||||||||||||||||||||
Irs2tm1Mfw/Irs2tm1Mfw Tg(Ins2-Irs2)13Mfw/0 |
||||||||||||||||||||||
Irs2tm1Mfw/Irs2tm1Mfw | ||||||||||||||||||||||
Irs2tm1Tka/Irs2tm1Tka | ||||||||||||||||||||||
Tg(Ins2-Irs2)13Mfw/0 | ||||||||||||||||||||||
Irs2tm1With/Irs2tm1With Tg(Ins2-cre)25Mgn/0 (conditional) |
||||||||||||||||||||||
Irs2tm1With/Irs2tm1With Tg(Nes-cre)1Kln/0 (conditional) |
||||||||||||||||||||||
Irs2tm2Mfw/Irs2tm2Mfw Tg(Ins2-cre)25Mgn/0 (conditional) |
||||||||||||||||||||||
Irs2tm2Tka/Irs2tm2Tka Tg(Ins2-cre)25Mgn/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 07/05/2024 MGI 6.24 |
|
|