Symbol
Name
ID

Cftr
cystic fibrosis transmembrane conductance regulator
MGI:88388

Phenotype annotations related to endocrine/exocrine glands

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Diabetes mellitus	Type I diabetes mellitus	Elevated sweat chloride	Exocrine pancreatic insufficiency	Pancreatitis	Pancreatic adenocarcinoma	Thyroiditis
Disease(s) Associated with CFTR	Diabetes mellitus	Type I diabetes mellitus	Elevated sweat chloride	Exocrine pancreatic insufficiency	Pancreatitis	Pancreatic adenocarcinoma	Thyroiditis
cystic fibrosis
pancreatic cancer
primary sclerosing cholangitis

Mouse Phenotypes

abnormal colon goblet cell morphology

pancreatic acinar cell zymogen granule accumulation

dilated pancreatic acinus

dilated pancreatic duct

abnormal Brunner's gland morphology

dilated Brunner's gland

abnormal crypts of Lieberkuhn morphology

abnormal large intestine crypts of Lieberkuhn morphology

abnormal small intestine crypts of Lieberkuhn morphology

dilated crypt of Lieberkuhn

abnormal salivary gland morphology

abnormal submandibular gland morphology

endocrine/exocrine gland phenotype

abnormal gland morphology

abnormal bile duct morphology

bile duct epithelium hyperplasia

abnormal lacrimal gland morphology

abnormal submucosal gland morphology

abnormal trachea gland morphology

abnormal gallbladder morphology

enlarged gallbladder

dilated gallbladder

abnormal pancreas morphology

small pancreas

decreased corpora lutea number

decreased ovary weight

small ovary

abnormal thymus involution

abnormal pancreas physiology

Availability

Mouse Genotype

Cftr^tm1.1Sdw/Cftr^tm1.1Sdw

Cftr^tm1Cam/Cftr^tm1Cam

Cftr^tm1Eur/Cftr^tm1Eur

Cftr^tm1Hsc/Cftr^tm1Hsc

Cftr^tm1Kth/Cftr^tm1Kth

Cftr^tm1Unc/Cftr^tm1Unc

Cftr^tm2Cam/Cftr^tm2Cam

Cftr^tm3Bay/Cftr^tm3Bay

Cftr^tm3Hgu/Cftr^tm3Hgu

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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