Symbol Name ID |
Insr
insulin receptor MGI:96575 |
Darker colors indicate more annotations |
Human Phenotypes | Type II diabetes mellitus |
Hyperinsulinemia |
Fasting hyperinsulinemia |
Hyperinsulinemic hypoglycemia |
Pancreatic islet-cell hyperplasia |
Elevated circulating insulin:C-peptide ratio |
Increased circulating renin level |
Hyperaldosteronism |
Central hypothyroidism |
Precocious puberty |
Disease(s) Associated with INSR | ||||||||||
Donohue syndrome | ||||||||||
familial hyperinsulinemic hypoglycemia 5 | ||||||||||
type 2 diabetes mellitus |
Mouse Phenotypes | abnormal pancreatic islet morphology |
abnormal pancreatic beta cell morphology |
decreased pancreatic beta cell mass |
increased pancreatic beta cell mass |
decreased pancreatic beta cell number |
pancreatic islet hyperplasia |
enlarged gallbladder |
decreased corpora lutea number |
decreased tertiary ovarian follicle number |
abnormal seminiferous tubule morphology |
decreased Leydig cell number |
decreased insulin secretion |
increased insulin secretion |
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Availability | Mouse Genotype | |||||||||||||
InsrM2Btlr/InsrM2Btlr | ||||||||||||||
Insrtm1Dac/Insr+ | ||||||||||||||
Insrtm1Khn/Insrtm1Khn Tg(Nes-cre)1Kln/0 (conditional) |
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Insrtm1Khn/Insrtm1Khn Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Tg(Ins2-cre)25Mgn/0 (conditional) |
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Insrtm1Khn/Insrtm1Khn Tg(Ins2-cre)25Mgn/0 (conditional) |
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Insrtm1Khn/Insrtm1Khn Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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Insrtm1Khn/Insrtm1Khn Tg(Slc2a4-cre)546Dac/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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