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Symbol Name ID |
Kras
Kirsten rat sarcoma viral oncogene homolog MGI:96680 |
| * | Aspects of the system are reported to show a normal phenotype. |
| ! | Indicates phenotype varies with strain background. |
| Darker colors indicate more annotations |
| Human Phenotypes | Low posterior hairline |
Cystic hygroma |
Thickened nuchal skin fold |
Short neck |
Webbed neck |
Lower limb asymmetry |
Hemihypertrophy |
Splenomegaly |
Hepatosplenomegaly |
Hepatomegaly |
Peritoneal abscess |
Aplasia/Hypoplasia of the abdominal wall musculature |
Bladder exstrophy |
Delayed menarche |
Short stature |
Tall stature |
Overgrowth |
Failure to thrive |
Failure to thrive in infancy |
Weight loss |
Asymmetric growth |
Growth delay |
Postnatal growth retardation |
| Disease(s) Associated with KRAS | |||||||||||||||||||||||
| autoimmune lymphoproliferative syndrome type 4 | |||||||||||||||||||||||
| cardiofaciocutaneous syndrome | |||||||||||||||||||||||
| linear nevus sebaceous syndrome | |||||||||||||||||||||||
| Lynch syndrome | |||||||||||||||||||||||
| multiple myeloma | |||||||||||||||||||||||
| Noonan syndrome | |||||||||||||||||||||||
| Noonan syndrome 3 | |||||||||||||||||||||||
| oculoectodermal syndrome | |||||||||||||||||||||||
| pancreatic cancer |
| Mouse Phenotypes | enlarged heart |
heart hyperplasia |
abnormal facial morphology |
triangular face |
flattened snout |
increased facial tumor incidence |
increased lip tumor incidence |
abnormal ear position |
embryonic growth retardation |
decreased embryo size |
increased pancreas weight |
enlarged pancreas |
pancreas cyst |
growth/size/body region phenotype |
slow postnatal weight gain |
cachexia |
abnormal peritoneum morphology |
decreased body length |
decreased body size |
fetal growth retardation |
distended abdomen |
increased lung weight |
enlarged liver |
enlarged spleen |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||
| Krastm1Mok/Krastm1Mok | |||||||||||||||||||||||||
| Krastm1Tyj/Krastm1Tyj | ! | ||||||||||||||||||||||||
| Krastm4.1Bbd/Krastm4.1Bbd | |||||||||||||||||||||||||
| Krastm4.1Bbd/Kras+ | |||||||||||||||||||||||||
| Krastm4.1Tyj/Kras+ | |||||||||||||||||||||||||
| Krastm4Tyj/Krastm4Tyj Tg(Pdx1-cre)89.1Dam/0 (conditional) |
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| Krastm1.1Khai/Kras+ Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Pdx1-cre)89.1Dam/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Pdx1-cre)6Tuv/? (conditional) |
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| Krastm4Tyj/Kras+ Ptf1atm1.1(cre)Cvw/Ptf1a+ (conditional) |
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| Krastm4Tyj/Kras+ Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Fabp7-cre,-lacZ)3Gtm/0 (conditional) |
* | ||||||||||||||||||||||||
| Krastm4Tyj/Kras+ (conditional) | |||||||||||||||||||||||||
| Krastm4Tyj/Kras+ Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
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| Krastm4Tyj/Kras+ Krt19tm1(cre/ERT)Ggu/Krt19+ (conditional) |
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| Krastm4Tyj/Kras+ Tg(Krt1-15-cre/PGR*)22Cot/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(IVL-cre/ERT2)1Blpn/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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