Symbol Name ID |
Shh
sonic hedgehog MGI:98297 |
Darker colors indicate more annotations |
Human Phenotypes | Branchial anomaly |
Short neck |
Omphalocele |
Congenital diaphragmatic hernia |
Short stature |
Failure to thrive in infancy |
Weight loss |
Growth delay |
Disease(s) Associated with SHH | ||||||||
Hirschsprung's disease | ||||||||
holoprosencephaly | ||||||||
hypoplastic or aplastic tibia with polydactyly | ||||||||
polydactyly | ||||||||
solitary median maxillary central incisor |
Mouse Phenotypes | absent alveolar process |
abnormal odontoblast morphology |
abnormal incisor morphology |
abnormal lower incisor morphology |
small incisors |
abnormal molar cusp morphology |
small molars |
abnormal tooth development |
abnormal ameloblast morphology |
absent enamel cord |
arrest of tooth development |
growth retardation of incisors |
growth retardation of molars |
abnormal dentin morphology |
abnormal enamel morphology |
malocclusion |
abnormal maxillary shelf morphology |
decreased maxillary shelf size |
abnormal nasal bone morphology |
absent palatine bone horizontal plate |
abnormal palatal shelf fusion at midline |
palatal shelves fail to meet at midline |
persistence of medial edge epithelium during palatal shelf fusion |
palatal shelf hypoplasia |
abnormal upper lip morphology |
abnormal palatal rugae morphology |
decreased palatal rugae number |
cleft secondary palate |
cleft palate |
embryonic growth retardation |
decreased embryo size |
decreased lean body mass |
decreased body weight |
lung cyst |
microcephaly |
acephaly |
decreased body size |
postnatal growth retardation |
abnormal prenatal growth/weight/body size |
decreased fetal size |
fetal growth retardation |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||
Shhtm1(EGFP/cre)Cjt/Shhtm1(EGFP/cre)Cjt | ||||||||||||||||||||||||||||||||||||||||||
Shhtm1.1Rseg/Shhtm1.1Rseg | ||||||||||||||||||||||||||||||||||||||||||
Shhtm1Amc/Shhtm1Amc | ||||||||||||||||||||||||||||||||||||||||||
Shhtm1Chg/Shhtm1Chg | ||||||||||||||||||||||||||||||||||||||||||
Shhtm1Ptch/Shhtm1Ptch | ||||||||||||||||||||||||||||||||||||||||||
Shhtm3(cre)Chg/Shhtm3(cre)Chg | ||||||||||||||||||||||||||||||||||||||||||
Shhtm1Amc/Shhtm1.1Rseg | ||||||||||||||||||||||||||||||||||||||||||
Shhtm1b(EUCOMM)Wtsi/Shh+ | ||||||||||||||||||||||||||||||||||||||||||
Tg(KRT14-Shh)#Cobm/0 | ||||||||||||||||||||||||||||||||||||||||||
Shhtm2Amc/Shhtm2Amc Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-cre)1Jaw/0 (conditional) |
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Shhtm2Amc/Shhtm2Amc Tg(Nes-cre)1Kln/0 (conditional) |
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Shhtm2Chg/Shh+ Edil3Tg(Sox2-cre)1Amc/Edil3+ (conditional) |
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Shhtm1Amc/Shhtm2Amc Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-cre)1Jaw/0 (conditional) |
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Shhtm1Amc/Shhtm2Amc Tg(KRT14-cre)1Amc/0 (conditional) |
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Shhtm1Amc/Shhtm2Amc Tg(Thy1-cre)703Vaw/? (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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