Symbol Name ID |
Myo6
myosin VI MGI:104785 |
Darker colors indicate more annotations |
Human Phenotypes | Abnormal vestibular function |
Sensorineural hearing impairment |
Progressive sensorineural hearing impairment |
Disease(s) Associated with MYO6 | |||
autosomal dominant nonsyndromic deafness 22 | |||
autosomal recessive nonsyndromic deafness 37 |
Mouse Phenotypes | abnormal kinocilium morphology |
abnormal outer hair cell kinocilium morphology |
abnormal cochlear hair cell development |
abnormal cochlear sensory epithelium morphology |
abnormal cochlear hair cell stereociliary bundle morphology |
abnormal inner hair cell stereociliary bundle morphology |
abnormal orientation of inner hair cell stereociliary bundles |
decreased inner hair cell stereocilia number |
fused inner hair cell stereocilia |
abnormal orientation of cochlear hair cell stereociliary bundles |
abnormal orientation of outer hair cell stereociliary bundles |
decreased outer hair cell stereocilia number |
fused outer hair cell stereocilia |
decreased cochlear hair cell stereocilia number |
cochlear inner hair cell degeneration |
cochlear outer hair cell degeneration |
cochlear hair cell degeneration |
abnormal cuticular plate morphology |
absent organ of Corti |
organ of Corti degeneration |
stria vascularis degeneration |
detached tectorial membrane |
cochlear degeneration |
decreased vestibular hair cell number |
abnormal vestibular hair cell stereociliary bundle morphology |
fused vestibular hair cell stereocilia |
vestibular hair cell degeneration |
abnormal crista ampullaris neuroepithelium morphology |
abnormal inner ear vestibule morphology |
utricular macular degeneration |
vestibular saccular macula degeneration |
abnormal otolithic membrane morphology |
abnormal auditory brainstem response |
abnormal auditory brainstem response waveform shape |
increased or absent threshold for auditory brainstem response |
absent cochlear nerve compound action potential |
impaired hearing |
deafness |
abnormal vestibular system physiology |
absent linear vestibular evoked potential |
reduced linear vestibular evoked potential |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||
Myo6chl/Myo6chl | ||||||||||||||||||||||||||||||||||||||||||
Myo6em1(IMPC)Tcp/Myo6em1(IMPC)Tcp | ||||||||||||||||||||||||||||||||||||||||||
Myo6em1Bcgen/Myo6em1Bcgen | ||||||||||||||||||||||||||||||||||||||||||
Myo6ksv/Myo6ksv | ||||||||||||||||||||||||||||||||||||||||||
Myo6mpc285H/Myo6mpc285H | ||||||||||||||||||||||||||||||||||||||||||
Myo6rsv/Myo6rsv | ||||||||||||||||||||||||||||||||||||||||||
Myo6sv-2J/Myo6sv-2J | ||||||||||||||||||||||||||||||||||||||||||
Myo6sv-4J/Myo6sv-4J | ||||||||||||||||||||||||||||||||||||||||||
Myo6sv/Myo6sv | ||||||||||||||||||||||||||||||||||||||||||
Myo6twt/Myo6twt | ||||||||||||||||||||||||||||||||||||||||||
Myo6em1Bcgen/Myo6+ | ||||||||||||||||||||||||||||||||||||||||||
Myo6Mhdatlc/Myo6+ | ||||||||||||||||||||||||||||||||||||||||||
Myo6sv/Myo6+ |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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