Symbol Name ID |
Rorc
RAR-related orphan receptor gamma MGI:104856 |
Darker colors indicate more annotations |
Human Phenotypes | Splenomegaly |
Disease(s) Associated with RORC | |
immunodeficiency 42 |
Mouse Phenotypes | increased thymocyte apoptosis |
increased T cell apoptosis |
decreased thymus weight |
thymus hypoplasia |
decreased thymocyte number |
enlarged spleen |
abnormal T cell differentiation |
abnormal CD8-positive, alpha-beta T cell differentiation |
abnormal T-helper 17 cell differentiation |
decreased double-negative T cell number |
increased double-negative T cell number |
decreased double-positive T cell number |
decreased B-2 B cell number |
increased B-1a cell number |
increased B-1b cell number |
decreased NK cell number |
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number |
increased effector memory CD4-positive, alpha-beta T cell number |
decreased CD4-positive, alpha-beta T cell number |
increased effector memory CD8-positive, alpha-beta T cell number |
decreased CD8-positive, naive alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
decreased T cell number |
abnormal T cell morphology |
abnormal CD4-positive, alpha beta T cell morphology |
abnormal CD4-positive, alpha-beta intraepithelial T cell morphology |
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology |
abnormal splenic cell ratio |
decreased IgG2c level |
decreased IgG3 level |
decreased IgG level |
decreased IgM level |
abnormal T cell physiology |
abnormal T-helper 17 cell physiology |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||
Rorcm1Btlr/Rorcm1Btlr | ||||||||||||||||||||||||||||||||||||
Rorcm2Btlr/Rorcm2Btlr | ||||||||||||||||||||||||||||||||||||
Rorcm3Btlr/Rorcm3Btlr | ||||||||||||||||||||||||||||||||||||
Rorctm1.1Zsun/Rorctm1.1Zsun | ||||||||||||||||||||||||||||||||||||
Rorctm1Amj/Rorctm1Amj | ||||||||||||||||||||||||||||||||||||
Rorctm1Litt/Rorctm1Litt | ||||||||||||||||||||||||||||||||||||
Rorctm2Litt/Rorctm2Litt | ||||||||||||||||||||||||||||||||||||
Tg(CD2-Rorc)#Staka/0 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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