Symbol Name ID |
Npm1
nucleophosmin 1 MGI:106184 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Acute myeloid leukemia |
Disease(s) Associated with NPM1 | |
acute myeloid leukemia |
Mouse Phenotypes | hematopoietic system phenotype |
abnormal granulocyte differentiation |
abnormal embryonic hematopoiesis |
enlarged spleen |
increased spleen weight |
abnormal common myeloid progenitor cell morphology |
abnormal thrombopoiesis |
myeloid hyperplasia |
extramedullary hematopoiesis |
anemia |
abnormal bone marrow cell morphology/development |
increased bone marrow cell number |
abnormal bone marrow hematopoietic cell morphology |
increased granulocyte monocyte progenitor cell number |
abnormal megakaryocyte morphology |
abnormal proerythroblast morphology |
increased mean corpuscular volume |
anisocytosis |
increased granulocyte number |
thrombocytosis |
increased mean platelet volume |
decreased B cell number |
increased monocyte cell number |
increased leukocyte cell number |
reticulocytopenia |
decreased hematopoietic stem cell number |
increased hematopoietic stem cell number |
abnormal spleen B cell follicle morphology |
abnormal bone marrow cell physiology |
abnormal hematopoietic stem cell physiology |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||||
Npm1tm1Ppp/Npm1tm1Ppp | |||||||||||||||||||||||||||||||
Npm1tm2Ppp/Npm1tm2Ppp | |||||||||||||||||||||||||||||||
Npm1Gt(OST331547)Lex/Npm1+ | * | ||||||||||||||||||||||||||||||
Npm1tm1Hft/Npm1+ | * | ||||||||||||||||||||||||||||||
Npm1tm1Ppp/Npm1+ | |||||||||||||||||||||||||||||||
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sor+ Npm1tm1Trow/Npm1+ (conditional) |
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Npm1tm1Gsva/Npm1+ Tg(Mx1-cre)1Cgn/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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