Symbol Name ID |
Kdm6a
lysine (K)-specific demethylase 6A MGI:1095419 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Decreased circulating IgA level |
Decreased circulating IgG2 level |
Decreased circulating total IgG |
Hemolytic anemia |
Decreased proportion of memory B cells |
Decreased proportion of CD4-positive, alpha-beta memory T cells |
Acute lymphoblastic leukemia |
T-cell acute lymphoblastic leukemias |
Autoimmune thrombocytopenia |
Lymphoma |
Splenomegaly |
Disease(s) Associated with KDM6A | |||||||||||
acute lymphoblastic leukemia | |||||||||||
Kabuki syndrome |
Mouse Phenotypes | hematopoietic system phenotype |
enlarged spleen |
increased spleen weight |
decreased common myeloid progenitor cell number |
abnormal erythropoiesis |
extramedullary hematopoiesis |
anemia |
abnormal bone marrow cell morphology/development |
increased granulocyte monocyte progenitor cell number |
abnormal megakaryocyte morphology |
decreased erythroid progenitor cell number |
decreased erythrocyte cell number |
decreased hemoglobin content |
decreased mean corpuscular volume |
increased nucleated erythrocyte cell number |
abnormal granulocyte morphology |
increased neutrophil cell number |
increased granulocyte number |
thrombocytopenia |
increased B cell number |
increased monocyte cell number |
decreased leukocyte cell number |
increased myeloid cell number |
increased hematopoietic stem cell number |
decreased megakaryocyte-erythroid progenitor cell number |
abnormal hematopoietic stem cell physiology |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||
Kdm6atm1.2Kaig/Kdm6atm1.2Kaig | |||||||||||||||||||||||||||
Kdm6atm1.1Afst/Kdm6atm1.1Afst Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ (conditional) |
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Kdm6atm1Cdcn/Kdm6atm1Cdcn Tg(CAG-cre/Esr1*)5Amc/0 (conditional) |
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Kdm6atm1.1Afst/Y Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ (conditional) |
* | ||||||||||||||||||||||||||
Kdm6atm1Cdcn/Y Tg(CAG-cre/Esr1*)5Amc/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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