Symbol
Name
ID

Irf4
interferon regulatory factor 4
MGI:1096873

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgA concentration	Increased circulating IgG concentration	Decreased circulating antibody concentration	Paraproteinemia	Anemia	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemias	Chronic lymphatic leukemia	Lymphoma	Multiple myeloma	Splenomegaly
Disease(s) Associated with IRF4	Increased circulating IgA concentration	Increased circulating IgG concentration	Decreased circulating antibody concentration	Paraproteinemia	Anemia	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemias	Chronic lymphatic leukemia	Lymphoma	Multiple myeloma	Splenomegaly
acute lymphoblastic leukemia
chronic lymphocytic leukemia
multiple myeloma

Mouse Phenotypes

decreased B cell proliferation

decreased T cell proliferation

abnormal thymus morphology

enlarged thymus

enlarged spleen

increased spleen weight

abnormal B cell differentiation

abnormal class switch recombination

arrested B cell differentiation

abnormal T-helper 1 cell differentiation

increased neutrophil cell number

decreased plasmacytoid dendritic cell number

decreased dendritic cell number

absent plasma cells

decreased lymphocyte cell number

increased lymphocyte cell number

abnormal memory B cell morphology

abnormal CD4-positive, alpha beta T cell morphology

abnormal spleen morphology

absent spleen germinal center

abnormal B cell physiology

abnormal B cell activation

decreased IgG1 level

decreased IgG level

decreased IgM level

decreased immunoglobulin level

Availability

Mouse Genotype

Irf4^em1(IMPC)Mbp/Irf4^em1(IMPC)Mbp

Irf4^m1Btlr/Irf4^m1Btlr

Irf4^M2Btlr/Irf4^M2Btlr

Irf4^tm1.1Rdf/Irf4^tm1.1Rdf

Irf4^tm1Mak/Irf4^tm1Mak

Irf4^M2Btlr/Irf4⁺

Ighg1^tm1(cre)Cgn/Ighg1⁺
Irf4^tm1Rdf/Irf4^tm1.1Rdf (conditional)

Irf4^tm1Rdf/Irf4^tm1.1Rdf (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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