Symbol Name ID |
Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta MGI:1098211 |
Darker colors indicate more annotations |
Human Phenotypes | Increased circulating IgM level |
Decreased circulating antibody level |
B lymphocytopenia |
Lymphoma |
Splenomegaly |
Disease(s) Associated with PIK3CD | |||||
immunodeficiency 14 |
Mouse Phenotypes | decreased B cell proliferation |
abnormal B cell differentiation |
impaired hematopoiesis |
increased neutrophil cell number |
decreased germinal center B cell number |
decreased mature B cell number |
decreased B-1 B cell number |
absent B-1 B cells |
decreased B-1a cell number |
decreased B-2 B cell number |
decreased marginal zone B cell number |
decreased B cell number |
decreased T follicular helper cell number |
decreased CD4-positive, alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
decreased T cell number |
increased lymphocyte cell number |
increased leukocyte cell number |
small spleen |
spleen hypoplasia |
absent spleen germinal center |
decreased spleen germinal center number |
decreased spleen germinal center size |
abnormal B cell physiology |
abnormal B cell calcium ion homeostasis |
decreased IgA level |
increased IgE level |
decreased IgG1 level |
decreased IgG2a level |
decreased IgG2b level |
decreased IgG3 level |
decreased IgG level |
decreased IgM level |
decreased immunoglobulin level |
abnormal platelet aggregation |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||
Pik3cdGt(OST451938)Lex/Pik3cdGt(OST451938)Lex | ||||||||||||||||||||||||||||||||||||
Pik3cdm2Btlr/Pik3cdm2Btlr | ||||||||||||||||||||||||||||||||||||
Pik3cdtm1.1Bvan/Pik3cdtm1.1Bvan | ||||||||||||||||||||||||||||||||||||
Pik3cdtm1Jni/Pik3cdtm1Jni | ||||||||||||||||||||||||||||||||||||
Pik3cdtm1Tnr/Pik3cdtm1Tnr | ||||||||||||||||||||||||||||||||||||
Pik3cdm2Btlr/Pik3cd+ | ||||||||||||||||||||||||||||||||||||
Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr Tnfrsf4tm2(cre)Nik/Tnfrsf4+ (conditional) |
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Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr Tg(Cd4-cre)1Cwi/0 (conditional) |
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Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr Cd19tm1(cre)Cgn/Cd19+ (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/02/2024 MGI 6.13 |
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