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Symbol
Name
ID

Smad3
SMAD family member 3
MGI:1201674

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Gastrointestinal hemorrhage	Subarachnoid hemorrhage	Bruising susceptibility	Hematological neoplasm	Hepatosplenomegaly
Disease(s) Associated with SMAD3	Gastrointestinal hemorrhage	Subarachnoid hemorrhage	Bruising susceptibility	Hematological neoplasm	Hepatosplenomegaly
Loeys-Dietz syndrome 3
Lynch syndrome
pancreatic cancer

Mouse Phenotypes

decreased B cell apoptosis

impaired neutrophil chemotaxis

abnormal B cell proliferation

abnormal T cell proliferation

thymus hypoplasia

abnormal thymus involution

abnormal CD4-positive T cell differentiation

extramedullary hematopoiesis

increased neutrophil cell number

increased monocyte cell number

increased leukocyte cell number

small spleen

spleen hypoplasia

abnormal leukocyte physiology

abnormal T cell physiology

abnormal T cell activation

Availability

Mouse Genotype

Smad3^tm1Cxd/Smad3^tm1Cxd

Smad3^tm1Xfw/Smad3^tm1Xfw

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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