Symbol Name ID |
Gfi1b
growth factor independent 1B MGI:1276578 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Abnormal bleeding |
Epistaxis |
Gastrointestinal hemorrhage |
Menorrhagia |
Prolonged bleeding following procedure |
Prolonged bleeding time |
Bruising susceptibility |
Ecchymosis |
Petechiae |
Myelofibrosis |
Increased RBC distribution width |
Reduced prothrombin consumption |
Reduced quantity of Von Willebrand factor |
Reduced von Willebrand factor activity |
Abnormality of thrombocytes |
Impaired collagen-induced platelet aggregation |
Impaired epinephrine-induced platelet aggregation |
Impaired thrombin-induced platelet aggregation |
Thrombocytopenia |
Macrothrombocytopenia |
Abnormal number of alpha granules |
Absence of alpha granules |
Myelodysplasia |
Splenomegaly |
Disease(s) Associated with GFI1B | ||||||||||||||||||||||||
gray platelet syndrome | ||||||||||||||||||||||||
platelet-type bleeding disorder 17 |
Mouse Phenotypes | hematopoietic system phenotype |
abnormal megakaryocyte differentiation |
abnormal embryonic erythropoiesis |
abnormal blood cell morphology/development |
abnormal erythropoiesis |
anemia |
abnormal bone marrow cell morphology/development |
absent erythroid progenitor cell |
abnormal megakaryocyte progenitor cell morphology |
decreased erythrocyte cell number |
absent erythrocytes |
decreased hemoglobin content |
decreased neutrophil cell number |
thrombocytopenia |
absent platelets |
increased lymphocyte cell number |
increased hematopoietic stem cell number |
abnormal embryonic erythrocyte morphology |
increased splenocyte number |
abnormal hematopoietic stem cell physiology |
|
Availability | Mouse Genotype | ||||||||||||||||||||
Gfi1btm1Sho/Gfi1btm1Sho | |||||||||||||||||||||
Gfi1btm1Tmo/Gfi1btm1Tmo | |||||||||||||||||||||
Gfi1btm1b(EUCOMM)Hmgu/Gfi1b+ | |||||||||||||||||||||
Gfi1btm1.1Haho/Gfi1btm1.1Haho Tg(Mx1-cre)1Cgn/0 (conditional) |
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Col1a1tm1(tetO-cre)Haho/? Gfi1btm1.1Haho/Gfi1btm1.1Haho (conditional) |
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Gfi1btm2Tmo/Gfi1btm2Tmo Tg(Mx1-cre)1Cgn/? (conditional) |
* |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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