Symbol Name ID |
Ikbkg
inhibitor of kappaB kinase gamma MGI:1338074 |
Darker colors indicate more annotations |
Human Phenotypes | Reduced natural killer cell activity |
Increased circulating IgA level |
Abnormal circulating IgG level |
Decreased circulating total IgM |
Increased circulating IgM level |
Dysgammaglobulinemia |
Retinal hemorrhage |
Eosinophilia |
Leukocytosis |
Superficial thrombophlebitis |
Disease(s) Associated with IKBKG | ||||||||||
Behcet's disease | ||||||||||
Bloch-Sulzberger syndrome | ||||||||||
ectodermal dysplasia and immunodeficiency 1 | ||||||||||
immunodeficiency 33 |
Mouse Phenotypes | increased T cell apoptosis |
increased B cell proliferation |
small thymus |
enlarged spleen |
abnormal B cell differentiation |
decreased immature B cell number |
abnormal bone marrow cell morphology/development |
absent megakaryocytes |
decreased mature B cell number |
decreased B-1 B cell number |
decreased follicular B cell number |
decreased marginal zone B cell number |
decreased B cell number |
decreased NK cell number |
decreased CD4-positive, alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
decreased NK T cell number |
decreased regulatory T cell number |
decreased T cell number |
decreased single-positive T cell number |
small spleen |
abnormal NK cell physiology |
abnormal NK T cell physiology |
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Availability | Mouse Genotype | |||||||||||||||||||||||
Ikbkgtm1.1Dwat/Ikbkg+ | ||||||||||||||||||||||||
Ikbkgtm1Mka/Ikbkg+ | ||||||||||||||||||||||||
Ikbkgm1Btlr/Y | ||||||||||||||||||||||||
Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr Tg(Alb1-cre)7Gsc/0 (conditional) |
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Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa Cd79atm1(cre)Reth/Cd79a+ (conditional) |
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Cd19tm1(cre)Cgn/Cd19+ Ikbkgtm1.1Mpa/Y (conditional) |
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Ikbkgtm1.1Chtr/Y Tg(Alb1-cre)7Gsc/0 (conditional) |
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Ikbkgtm1.1Mpa/Y Tg(Cd4-cre)1Cwi/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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