Symbol Name ID |
Dkc1
dyskeratosis congenita 1, dyskerin MGI:1861727 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Bone marrow hypocellularity |
Pancytopenia |
Aplastic anemia |
Anemia |
Leukopenia |
Abnormality of neutrophils |
Acute myeloid leukemia |
Abnormality of coagulation |
Thrombocytopenia |
Lymphoma |
Hodgkin lymphoma |
Myelodysplasia |
Splenomegaly |
Disease(s) Associated with DKC1 | |||||||||||||
aplastic anemia | |||||||||||||
dyskeratosis congenita | |||||||||||||
X-linked dyskeratosis congenita |
Mouse Phenotypes | hematopoietic system phenotype |
decreased hematopoietic stem cell proliferation |
enlarged spleen |
abnormal hematopoietic system morphology/development |
abnormal definitive hematopoiesis |
decreased common myeloid progenitor cell number |
extramedullary hematopoiesis |
anemia |
abnormal bone marrow cell morphology/development |
decreased bone marrow cell number |
decreased erythroid progenitor cell number |
abnormal erythrocyte morphology |
decreased hemoglobin content |
thrombocytopenia |
decreased B cell number |
decreased pre-B cell number |
decreased T cell number |
decreased lymphocyte cell number |
decreased leukocyte cell number |
abnormal spleen morphology |
decreased spleen red pulp amount |
decreased spleen white pulp amount |
abnormal hematopoietic system physiology |
abnormal bone marrow cell physiology |
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Availability | Mouse Genotype | ||||||||||||||||||||||||
Dkc1tm1.1Pjma/Dkc1+ | |||||||||||||||||||||||||
Dkc1tm1Ppp/Dkc1+ | |||||||||||||||||||||||||
Dkc1tm1.1Pjma/Y | * | ||||||||||||||||||||||||
Dkc1tm1Ppp/Y |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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