About Help FAQ

Symbol
Name
ID

Btk
Bruton agammaglobulinemia tyrosine kinase
MGI:88216

Phenotype annotations related to hematopoietic system

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Agammaglobulinemia	Gastrointestinal hemorrhage	Abnormal bone marrow cell morphology	Anemia	Neutropenia	Decreased proportion of CD4-positive helper T cells	Thrombocytopenia	Abnormality of the spleen
Disease(s) Associated with BTK	Agammaglobulinemia	Gastrointestinal hemorrhage	Abnormal bone marrow cell morphology	Anemia	Neutropenia	Decreased proportion of CD4-positive helper T cells	Thrombocytopenia	Abnormality of the spleen
Burkitt lymphoma
X-linked agammaglobulinemia

Mouse Phenotypes

abnormal B cell proliferation

decreased B cell proliferation

impaired neutrophil phagocytosis

abnormal lymphopoiesis

abnormal B cell differentiation

decreased immature B cell number

decreased transitional stage B cell number

increased immature B cell number

increased pro-B cell number

impaired myelopoiesis

abnormal bone marrow cell number

decreased neutrophil cell number

decreased mature B cell number

absent mature B cells

decreased B-1 B cell number

absent B-1a cells

decreased follicular B cell number

decreased B cell number

increased CD4-positive, alpha-beta T cell number

abnormal leukocyte morphology

abnormal pre-B cell morphology

spleen hypoplasia

decreased spleen germinal center number

decreased spleen germinal center size

decreased splenocyte number

abnormal neutrophil physiology

abnormal B cell physiology

abnormal B cell activation

abnormal B cell calcium ion homeostasis

decreased IgD level

increased IgE level

decreased IgG3 level

increased IgG level

decreased IgM level

increased IgM level

decreased immunoglobulin level

abnormal macrophage physiology

Availability

Mouse Genotype

Btk^m1Anu/Btk^m1Anu

Btk^m2Anu/Btk^m2Anu

Btk^tm1Wk/Btk^tm1Wk

Btk^tm1Wk/Btk^tm1Wk
Tg(IGH-Btk)1Witt/0

Btk^vila/Btk^vila

Btk^xid/Btk^xid

!

!

!

!

!

Btk^xid/?
Tg(IGH-Btk)1Witt/Tg(IGH-Btk)1Witt

Btk^tm1Gsv/Btk⁺

Btk^{tm1a(EUCOMM)Hmgu}/Y

Btk^tm1Gsv/Y

Btk^xid/Y

Btk^xid/?
Tg(IGH-Btk)1Witt/0

Btk^xid/?

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/02/2024 MGI 6.13