Symbol Name ID |
Fcgr3
Fc receptor, IgG, low affinity III MGI:95500 |
Darker colors indicate more annotations |
Human Phenotypes | Increased circulating IgA concentration |
Increased circulating IgE concentration |
Increased circulating IgG concentration |
Decreased circulating antibody concentration |
Paraproteinemia |
Abnormality of blood and blood-forming tissues |
Abnormal bleeding |
Bleeding with minor or no trauma |
Epistaxis |
Gingival bleeding |
Gastrointestinal hemorrhage |
Hematemesis |
Melena |
Intracranial hemorrhage |
Intraventricular hemorrhage |
Joint hemorrhage |
Muscle hemorrhage |
Menorrhagia |
Oral cavity bleeding |
Persistent bleeding after trauma |
Prolonged bleeding time |
Bruising susceptibility |
Purpura |
Petechiae |
Spontaneous hematomas |
Abnormal megakaryocyte morphology |
Increased megakaryocyte colony forming unit count |
Megakaryocytopenia |
Reduced erythrocyte adenylate kinase activity |
Reticulocytosis |
Anemia |
Hemolytic anemia |
Anemia of inadequate production |
Poikilocytosis |
Acanthocytosis |
Leukocytosis |
Leukopenia |
Arterial thrombosis |
Thromboembolism |
Hyperfibrinogenemia |
Reduced factor VIII activity |
Prolonged partial thromboplastin time |
Abnormality of thrombocytes |
Thrombocytopenia |
Congenital thrombocytopenia |
Intermittent thrombocytopenia |
Abnormal platelet shape |
Abnormal platelet volume |
Decreased mean platelet volume |
Lymphoma |
Multiple myeloma |
Elevated erythrocyte sedimentation rate |
Splenic rupture |
Splenomegaly |
Hepatosplenomegaly |
Disease(s) Associated with FCGR2A | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
autoimmune thrombocytopenic purpura | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
cystic fibrosis | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
factor VIII deficiency | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
hemolytic anemia | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
malaria | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
multiple myeloma | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
non-Hodgkin lymphoma | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
rheumatoid arthritis | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
systemic lupus erythematosus | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
temporal arteritis | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
thrombocytopenia | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
Disease(s) Associated with FCGR2B | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
autoimmune thrombocytopenic purpura | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
malaria | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
systemic lupus erythematosus |
Mouse Phenotypes | decreased B cell apoptosis |
decreased mast cell degranulation |
impaired macrophage phagocytosis |
enlarged spleen |
anemia |
decreased susceptibility to autoimmune hemolytic anemia |
increased neutrophil cell number |
abnormal leukocyte cell number |
increased germinal center B cell number |
abnormal mast cell physiology |
abnormal neutrophil physiology |
impaired neutrophil recruitment |
increased IgA level |
increased IgG1 level |
increased IgG2a level |
increased IgG2b level |
increased IgG3 level |
increased IgG level |
increased IgM level |
increased immunoglobulin level |
impaired natural killer cell mediated cytotoxicity |
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Availability | Mouse Genotype | |||||||||||||||||||||
Fcgr2btm1Ttk/Fcgr2btm1Ttk | ||||||||||||||||||||||
Fcgr3tm1Jsv/Fcgr3tm1Jsv | ||||||||||||||||||||||
Fcgr2btm1Kgcs/Fcgr2b+ |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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