Symbol Name ID |
Il10
interleukin 10 MGI:96537 |
Darker colors indicate more annotations |
Human Phenotypes | Increased circulating IgA concentration |
Increased circulating IgE concentration |
Increased circulating IgG concentration |
Monoclonal immunoglobulin M proteinemia |
Polyclonal elevation of IgM |
Decreased circulating antibody concentration |
Paraproteinemia |
Abnormality of blood and blood-forming tissues |
Abnormal bleeding |
Bleeding with minor or no trauma |
Epistaxis |
Gingival bleeding |
Gastrointestinal hemorrhage |
Hematemesis |
Melena |
Retinal hemorrhage |
Intracranial hemorrhage |
Intraventricular hemorrhage |
Joint hemorrhage |
Muscle hemorrhage |
Diffuse alveolar hemorrhage |
Localized pulmonary hemorrhage |
Menorrhagia |
Oral cavity bleeding |
Persistent bleeding after trauma |
Prolonged bleeding time |
Bruising susceptibility |
Purpura |
Petechiae |
Spontaneous hematomas |
Abnormal megakaryocyte morphology |
Increased megakaryocyte colony forming unit count |
Megakaryocytopenia |
Anemia |
Hemolytic anemia |
Anemia of inadequate production |
Normocytic anemia |
Poikilocytosis |
Acanthocytosis |
Leukocytosis |
Leukopenia |
Impaired lymphocyte transformation with phytohemagglutinin |
Abnormal granulocyte morphology |
Abnormal basophil morphology |
Abnormality of neutrophils |
Granulomatosis |
Hemophagocytosis |
Leukemia |
Ph-positive acute lymphoblastic leukemia |
Chronic myelogenous leukemia |
Myeloproliferative disorder |
Thromboembolism |
Superficial thrombophlebitis |
Reduced factor VIII activity |
Hypercoagulability |
Prolonged partial thromboplastin time |
Thrombocytopenia |
Congenital thrombocytopenia |
Intermittent thrombocytopenia |
Thrombocytosis |
Abnormal platelet shape |
Abnormal platelet volume |
Decreased mean platelet volume |
Lymphoma |
Multiple myeloma |
Elevated erythrocyte sedimentation rate |
Splenic rupture |
Splenomegaly |
Hepatosplenomegaly |
Disease(s) Associated with IL10 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
autoimmune thrombocytopenic purpura | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Behcet's disease | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
chronic myeloid leukemia | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
factor VIII deficiency | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
graft-versus-host disease | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
granulomatosis with polyangiitis | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lymphoplasmacytic lymphoma | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
multiple myeloma | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
pancreatic cancer | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
rheumatoid arthritis | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
systemic lupus erythematosus | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
thrombocytopenia |
Mouse Phenotypes | decreased T cell proliferation |
increased thymus weight |
thymus hyperplasia |
spleen hyperplasia |
abnormal myelopoiesis |
anemia |
hypochromic anemia |
microcytic anemia |
absent erythroid progenitor cell |
decreased erythrocyte cell number |
decreased hemoglobin content |
increased granulocyte number |
increased myeloid dendritic cell number |
abnormal lymphocyte cell number |
increased plasma cell number |
increased B cell number |
increased CD4-positive, alpha-beta T cell number |
increased T cell number |
abnormal leukocyte morphology |
abnormal myeloid leukocyte morphology |
decreased spleen iron level |
decreased spleen red pulp amount |
increased IgE level |
increased IgG1 level |
increased IgG2a level |
abnormal CD8-positive, alpha-beta T cell physiology |
abnormal regulatory T cell physiology |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||
Il10tm1.1Roer/Il10tm1.1Roer | ||||||||||||||||||||||||||||
Il10tm1Cgn/Il10tm1Cgn | ||||||||||||||||||||||||||||
Il10tm1Roer/Il10tm1Roer Foxp3tm4(YFP/icre)Ayr/Y (conditional) |
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Cd19tm1(cre)Cgn/Cd19+ Il10tm1Roer/Il10tm1Roer (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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