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Symbol
Name
ID

Itgb2
integrin beta 2
MGI:96611

Phenotype annotations related to hematopoietic system

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Abnormal bleeding	Bone marrow hypocellularity	Polycythemia	Leukocytosis	Abnormality of neutrophil physiology	Impaired neutrophil chemotaxis	Acute myeloid leukemia	Hyperfibrinogenemia	Impaired platelet aggregation	Thrombocytosis
Disease(s) Associated with ITGB2	Abnormal bleeding	Bone marrow hypocellularity	Polycythemia	Leukocytosis	Abnormality of neutrophil physiology	Impaired neutrophil chemotaxis	Acute myeloid leukemia	Hyperfibrinogenemia	Impaired platelet aggregation	Thrombocytosis
leukocyte adhesion deficiency
leukocyte adhesion deficiency 1

Mouse Phenotypes

abnormal leukocyte migration

abnormal leukocyte adhesion

abnormal T cell proliferation

decreased T cell proliferation

enlarged spleen

abnormal NK cell differentiation

abnormal T cell differentiation

myeloid hyperplasia

increased bone marrow cell number

increased basophil cell number

increased eosinophil cell number

decreased neutrophil cell number

increased neutrophil cell number

increased granulocyte number

abnormal neutrophil morphology

thrombocytosis

decreased dendritic cell number

increased dendritic cell number

increased B-1b cell number

decreased B cell number

increased B cell number

increased effector memory CD4-positive, alpha-beta T cell number

increased T-helper 1 cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased NK T cell number

decreased single-positive T cell number

increased T cell number

increased lymphocyte cell number

decreased macrophage cell number

increased monocyte cell number

increased leukocyte cell number

abnormal spleen morphology

abnormal spleen red pulp morphology

abnormal leukocyte physiology

abnormal neutrophil physiology

impaired neutrophil recruitment

increased IgA level

increased IgE level

decreased IgG level

increased IgG level

increased IgM level

increased immunoglobulin level

impaired natural killer cell mediated cytotoxicity

abnormal T cell physiology

abnormal cytotoxic T cell cytolysis

abnormal T cell activation

Availability

Mouse Genotype

Itgb2^M1Btlr/Itgb2^M1Btlr

Itgb2^m3Btlr/Itgb2^m3Btlr

Itgb2^M4Btlr/Itgb2^M4Btlr

Itgb2^m5Btlr/Itgb2^m5Btlr

Itgb2^tm1.1Arte/Itgb2^tm1.1Arte

Itgb2^tm1Bay/Itgb2^tm1Bay

!

Itgb2^tm2Bay/Itgb2^tm2Bay

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24