Symbol Name ID |
Itpa
inosine triphosphatase (nucleoside triphosphate pyrophosphatase) MGI:96622 |
Darker colors indicate more annotations |
Human Phenotypes | Increased circulating IgA level |
Increased circulating IgE level |
Abnormal bleeding |
Epistaxis |
Gingival bleeding |
Joint hemorrhage |
Menorrhagia |
Persistent bleeding after trauma |
Prolonged bleeding time |
Bruising susceptibility |
Purpura |
Petechiae |
Spontaneous hematomas |
Abnormal megakaryocyte morphology |
Increased megakaryocyte colony forming unit count |
Megakaryocytopenia |
Reduced erythrocyte adenylate kinase activity |
Reticulocytosis |
Hemolytic anemia |
Anemia of inadequate production |
Poikilocytosis |
Acanthocytosis |
Leukocytosis |
Acute lymphoblastic leukemia |
T-cell acute lymphoblastic leukemias |
Thrombocytopenia |
Congenital thrombocytopenia |
Intermittent thrombocytopenia |
Abnormal platelet shape |
Abnormal platelet volume |
Decreased mean platelet volume |
Lymphoma |
Elevated erythrocyte sedimentation rate |
Splenomegaly |
Disease(s) Associated with ITPA | ||||||||||||||||||||||||||||||||||
acute lymphoblastic leukemia | ||||||||||||||||||||||||||||||||||
hemolytic anemia | ||||||||||||||||||||||||||||||||||
rheumatoid arthritis | ||||||||||||||||||||||||||||||||||
thrombocytopenia |
Mouse Phenotypes | extramedullary hematopoiesis |
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Availability | Mouse Genotype | |
Itpatm1Skmi/Itpatm1Skmi |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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