Symbol
Name
ID

Mdm2
transformed mouse 3T3 cell double minute 2
MGI:96952

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Abnormality of blood and blood-forming tissues	Leukocytosis	Abnormal granulocyte morphology	Abnormal basophil morphology	Ph-positive acute lymphoblastic leukemia	Chronic myelogenous leukemia	Myeloproliferative disorder	Thrombocytopenia	Thrombocytosis	Splenomegaly
Disease(s) Associated with MDM2
chronic myeloid leukemia

Mouse Phenotypes

decreased thymocyte apoptosis

decreased thymus weight

thymus hypoplasia

decreased thymocyte number

enlarged spleen

abnormal B cell differentiation

decreased immature B cell number

decreased double-negative T cell number

decreased double-positive T cell number

anemia

decreased bone marrow cell number

decreased erythrocyte cell number

decreased neutrophil cell number

decreased granulocyte number

decreased T cell number

decreased lymphocyte cell number

decreased leukocyte cell number

decreased spleen weight

spleen hypoplasia

abnormal hematopoietic system physiology

Availability

Mouse Genotype

Mdm2^tm1Glo/Mdm2^tm1Glo

Mdm2^tm2.1Snj/Mdm2^tm2.1Snj

Mdm2^tm1Bay/Mdm2^tm1Mep

Mdm2^tm1Mep/Mdm2^tm1.1Mep

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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