Symbol Name ID |
Tgfb1
transforming growth factor, beta 1 MGI:98725 |
Darker colors indicate more annotations |
Human Phenotypes | Increased circulating IgA level |
Increased circulating IgG level |
Decreased circulating antibody level |
Paraproteinemia |
Bleeding with minor or no trauma |
Epistaxis |
Gingival bleeding |
Gastrointestinal hemorrhage |
Hematemesis |
Melena |
Intracranial hemorrhage |
Intraventricular hemorrhage |
Joint hemorrhage |
Muscle hemorrhage |
Oral cavity bleeding |
Persistent bleeding after trauma |
Bruising susceptibility |
Purpura |
Petechiae |
Spontaneous hematomas |
Bone marrow hypocellularity |
Aplastic anemia |
Anemia |
Eosinophilia |
Thromboembolism |
Superficial thrombophlebitis |
Reduced factor VIII activity |
Prolonged partial thromboplastin time |
Multiple myeloma |
Elevated erythrocyte sedimentation rate |
Splenic rupture |
Splenomegaly |
Hepatosplenomegaly |
Disease(s) Associated with TGFB1 | |||||||||||||||||||||||||||||||||
aplastic anemia | |||||||||||||||||||||||||||||||||
Behcet's disease | |||||||||||||||||||||||||||||||||
Camurati-Engelmann disease | |||||||||||||||||||||||||||||||||
cystic fibrosis | |||||||||||||||||||||||||||||||||
eosinophilic esophagitis | |||||||||||||||||||||||||||||||||
factor VIII deficiency | |||||||||||||||||||||||||||||||||
multiple myeloma |
Mouse Phenotypes | increased T cell proliferation |
abnormal embryonic hematopoiesis |
abnormal embryonic erythropoiesis |
decreased thymus weight |
thymus hypoplasia |
abnormal T cell differentiation |
abnormal T-helper 17 cell differentiation |
decreased Langerhans cell number |
absent Langerhans cell |
abnormal T cell subpopulation ratio |
increased T-helper 1 cell number |
decreased T-helper 17 cell number |
decreased CD4-positive, alpha-beta T cell number |
increased CD4-positive, alpha-beta T cell number |
increased regulatory T cell number |
increased monocyte cell number |
increased leukocyte cell number |
abnormal T cell morphology |
decreased spleen weight |
small spleen |
spleen hypoplasia |
abnormal T cell activation |
abnormal regulatory T cell physiology |
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Availability | Mouse Genotype | |||||||||||||||||||||||
Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul | ||||||||||||||||||||||||
Tgfb1tm1Doe/Tgfb1tm1Doe | ||||||||||||||||||||||||
Tgfb1tm1N/Tgfb1tm1N | ||||||||||||||||||||||||
Tgfb1tm1Rif/Tgfb1tm1Rif | ||||||||||||||||||||||||
B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv Tg(CD207-cre)1Dhka/? (conditional) |
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B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv Tg(Cd4-cre)1Cwi/0 (conditional) |
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Tg(Lck-cre)548Jxm/? Tgfb1tm2.1Doe/Tgfb1tm2.1Doe (conditional) |
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Tgfb1tm3.1Flv/Tgfb1tm3.1Flv Tg(Cd4-cre)1Cwi/0 (conditional) |
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B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv Tg(Cd4-cre)1Cwi/0 (conditional) |
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B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv Tnfrsf4tm2(cre)Nik/Tnfrsf4+ (conditional) |
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B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv Foxp3tm4(YFP/icre)Ayr/Foxp3+ (conditional) |
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Tgfb1tm2Flv/B9d2/Tgfb1tm1Flv Tg(CD207-cre)1Dhka/? (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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