Symbol Name ID |
Zap70
zeta-chain (TCR) associated protein kinase MGI:99613 |
Darker colors indicate more annotations |
Human Phenotypes | Decreased lymphocyte proliferation in response to mitogen |
Panhypogammaglobulinemia |
Autoimmune hemolytic anemia |
Eosinophilia |
Abnormal B cell count |
Decreased proportion of CD8-positive T cells |
Absence of CD8-positive T cells |
Lymphocytosis |
Impaired lymphocyte transformation with phytohemagglutinin |
Autoimmune thrombocytopenia |
Lymphoma |
Lymphoproliferative disorder |
Splenomegaly |
Hepatosplenomegaly |
Disease(s) Associated with ZAP70 | ||||||||||||||
immunodeficiency 48 |
Mouse Phenotypes | decreased T cell proliferation |
abnormal thymus cell ratio |
thymus hypoplasia |
abnormal thymocyte activation |
abnormal class switch recombination |
abnormal T cell differentiation |
abnormal CD8-positive, alpha-beta T cell differentiation |
abnormal T cell selection |
abnormal T cell clonal deletion |
abnormal positive T cell selection |
abnormal double-positive T cell morphology |
increased double-positive T cell number |
arrested T cell differentiation |
impaired hematopoiesis |
increased B cell number |
abnormal T cell subpopulation ratio |
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number |
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number |
increased central memory CD4-positive, alpha-beta T cell number |
increased effector memory CD4-positive, alpha-beta T cell number |
decreased CD4-positive, alpha-beta T cell number |
absent CD4-positive, alpha-beta T cells |
increased central memory CD8 positive, alpha-beta T cell number |
decreased CD8-positive, naive alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
absent CD8-positive, alpha-beta T cells |
increased memory T cell number |
abnormal regulatory T cell number |
decreased regulatory T cell number |
decreased T cell number |
absent T cells |
increased activated T cell number |
abnormal CD4-positive, alpha beta T cell morphology |
abnormal splenic cell ratio |
increased IgE level |
increased IgG1 level |
increased IgG2b level |
decreased IgG level |
increased immunoglobulin level |
abnormal T cell physiology |
abnormal T cell activation |
abnormal regulatory T cell physiology |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||
Zap70m1Btlr/Zap70m1Btlr | |||||||||||||||||||||||||||||||||||||||||||
Zap70m1Saka/Zap70m1Saka | |||||||||||||||||||||||||||||||||||||||||||
Zap70m2Btlr/Zap70m2Btlr | |||||||||||||||||||||||||||||||||||||||||||
Zap70m3Btlr/Zap70m3Btlr | |||||||||||||||||||||||||||||||||||||||||||
Zap70m4Btlr/Zap70m4Btlr | |||||||||||||||||||||||||||||||||||||||||||
Zap70m5Btlr/Zap70m5Btlr | |||||||||||||||||||||||||||||||||||||||||||
Zap70m6Btlr/Zap70m6Btlr | |||||||||||||||||||||||||||||||||||||||||||
Zap70m6Hefl/Zap70m6Hefl | |||||||||||||||||||||||||||||||||||||||||||
Zap70m7Btlr/Zap70m7Btlr | |||||||||||||||||||||||||||||||||||||||||||
Zap70m8Btlr/Zap70m8Btlr | |||||||||||||||||||||||||||||||||||||||||||
Zap70mrtle/Zap70mrtle | |||||||||||||||||||||||||||||||||||||||||||
Zap70mur/Zap70mur | |||||||||||||||||||||||||||||||||||||||||||
Zap70st/Zap70st | |||||||||||||||||||||||||||||||||||||||||||
Zap70tm1Dlo/Zap70tm1Dlo | |||||||||||||||||||||||||||||||||||||||||||
Zap70tm1Weis/Zap70tm1Weis | |||||||||||||||||||||||||||||||||||||||||||
Zap70tm2.1Weis/Zap70tm2.1Weis | |||||||||||||||||||||||||||||||||||||||||||
Zap70m1Saka/Zap70tm2.1Weis | |||||||||||||||||||||||||||||||||||||||||||
Zap70m6Hefl/Zap70tm1Weis | |||||||||||||||||||||||||||||||||||||||||||
Zap70mrtle/Zap70rps | |||||||||||||||||||||||||||||||||||||||||||
Zap70st/Zap70tm1Dlo |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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