Symbol Name ID |
Lig4
ligase IV, DNA, ATP-dependent MGI:1335098 |
Darker colors indicate more annotations |
Human Phenotypes | Increased circulating IgA concentration |
Increased circulating IgG concentration |
Decreased circulating antibody concentration |
Paraproteinemia |
Hypercalcemia |
Elevated circulating creatinine concentration |
Hyperproteinemia |
Elevated circulating hepatic transaminase concentration |
Diabetes mellitus |
Type II diabetes mellitus |
Pleural effusion |
Abnormality of vitamin B12 metabolism |
Amyloidosis |
Disease(s) Associated with LIG4 | |||||||||||||
DNA ligase IV deficiency | |||||||||||||
multiple myeloma | |||||||||||||
pancreatic cancer |
Mouse Phenotypes | abnormal DNA repair |
abnormal double-strand DNA break repair |
|
Availability | Mouse Genotype | ||
Lig4tiny/Lig4tiny | |||
Lig4tm1Pmc/Lig4tm1Pmc Tg(Nes-cre)1Kln/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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