Symbol Name ID |
Nr1h4
nuclear receptor subfamily 1, group H, member 4 MGI:1352464 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Conjugated hyperbilirubinemia |
Hyperammonemia |
Elevated circulating alpha-fetoprotein concentration |
Elevated circulating alanine aminotransferase concentration |
Elevated circulating aspartate aminotransferase concentration |
Hypoglycemia |
Nonimmune hydrops fetalis |
Pleural effusion |
Ascites |
Disease(s) Associated with NR1H4 | |||||||||
progressive familial intrahepatic cholestasis 5 |
Mouse Phenotypes | homeostasis/metabolism phenotype |
abnormal blood homeostasis |
increased circulating bilirubin level |
decreased circulating glucose level |
decreased circulating insulin level |
increased circulating cholesterol level |
decreased circulating free fatty acids level |
increased circulating phospholipid level |
increased circulating triglyceride level |
increased circulating alanine transaminase level |
increased circulating aspartate transaminase level |
decreased body temperature |
increased energy expenditure |
impaired glucose tolerance |
abnormal bile salt homeostasis |
abnormal bile salt level |
increased bile salt level |
increased liver cholesterol level |
increased liver triglyceride level |
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Availability | Mouse Genotype | |||||||||||||||||||
Nr1h4tm1.1Mbj/Nr1h4tm1.1Mbj | * | |||||||||||||||||||
Nr1h4tm1.2Auw/Nr1h4tm1.2Auw | ||||||||||||||||||||
Nr1h4tm1Gonz/Nr1h4tm1Gonz | * | |||||||||||||||||||
Nr1h4tm1Kok/Nr1h4tm1Kok | ||||||||||||||||||||
Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz Tg(Vil1-cre)997Gum/0 (conditional) |
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Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz Tg(Alb1-cre)1Dlr/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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