Symbol Name ID |
Il6
interleukin 6 MGI:96559 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Monoclonal immunoglobulin M proteinemia |
Polyclonal elevation of IgM |
Periorbital edema |
Pedal edema |
Abnormality of metabolism/homeostasis |
Decreased level of 1,5 anhydroglucitol in serum |
Elevated erythrocyte sedimentation rate |
Decreased resting energy expenditure |
Hyperglycemia |
Diabetes mellitus |
Type II diabetes mellitus |
Insulin resistance |
Ketoacidosis |
Pleural effusion |
Fever |
Hepatic steatosis |
Increased level of L-fucose in urine |
Increased circulating free T3 |
Increased circulating free T4 concentration |
Decreased thyroid-stimulating hormone level |
Disease(s) Associated with IL6 | ||||||||||||||||||||
Graves' disease | ||||||||||||||||||||
Hodgkin's lymphoma | ||||||||||||||||||||
lymphoplasmacytic lymphoma | ||||||||||||||||||||
metabolic dysfunction-associated steatotic liver disease | ||||||||||||||||||||
obesity | ||||||||||||||||||||
Sjogren's syndrome | ||||||||||||||||||||
stomach cancer | ||||||||||||||||||||
type 1 diabetes mellitus | ||||||||||||||||||||
type 2 diabetes mellitus |
Mouse Phenotypes | homeostasis/metabolism phenotype |
increased susceptibility to dopaminergic neuron neurotoxicity |
decreased glucagon secretion |
decreased insulin secretion |
abnormal homeostasis |
increased circulating glucose level |
increased circulating interleukin-10 level |
decreased circulating interleukin-12 level |
increased body temperature |
impaired febrile response |
abnormal dopamine level |
decreased dopamine level |
abnormal oxygen consumption |
abnormal glucose homeostasis |
impaired glucose tolerance |
abnormal acute phase protein level |
abnormal interferon level |
abnormal exercise endurance |
decreased incidence of tumors by chemical induction |
abnormal bone healing |
delayed wound healing |
impaired wound healing |
decreased susceptibility to injury |
|
Availability | Mouse Genotype | |||||||||||||||||||||||
Il6tm1Kopf/Il6tm1Kopf | ||||||||||||||||||||||||
Il6tm1Mur/Il6tm1Mur | ||||||||||||||||||||||||
Il6tm1Poli/Il6tm1Poli | * | |||||||||||||||||||||||
Il6tm1Mur/Il6+ |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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