Symbol Name ID |
Lipa
lysosomal acid lipase A MGI:96789 |
Darker colors indicate more annotations |
Human Phenotypes | Decreased HDL cholesterol concentration |
Increased LDL cholesterol concentration |
Hypercholesterolemia |
Hypertriglyceridemia |
Elevated circulating alanine aminotransferase concentration |
Elevated circulating aspartate aminotransferase concentration |
Increased circulating lactate dehydrogenase concentration |
Elevated gamma-glutamyltransferase level |
Low alkaline phosphatase |
Reduced lysosomal acid lipase activity |
Fever |
Hepatic steatosis |
Ascites |
Adrenal calcification |
Disease(s) Associated with LIPA | ||||||||||||||
cholesterol ester storage disease | ||||||||||||||
Wolman disease |
Mouse Phenotypes | abnormal lipid oxidation |
decreased susceptibility to diet-induced obesity |
increased circulating insulin level |
increased circulating ketone body level |
decreased circulating HDL cholesterol level |
increased circulating LDL cholesterol level |
increased circulating cholesterol level |
increased circulating free fatty acids level |
increased circulating alanine transaminase level |
increased circulating aspartate transaminase level |
increased respiratory quotient |
impaired gluconeogenesis |
improved glucose tolerance |
increased insulin sensitivity |
insulin resistance |
increased liver cholesterol level |
abnormal lipid level |
decreased unsaturated fatty acids level |
increased unsaturated fatty acids level |
decreased liver triglyceride level |
increased liver triglyceride level |
abnormal carbohydrate metabolism |
abnormal enzyme/coenzyme activity |
decreased triglyceride lipase activity |
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Availability | Mouse Genotype | ||||||||||||||||||||||||
Lipatm1Ggb/Lipatm1Ggb | |||||||||||||||||||||||||
Lipatm1c(EUCOMM)Hmgu/Lipatm1c(EUCOMM)Hmgu Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1Tg(Alb-cre)21Mgn (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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