Symbol Name ID |
Irs1
insulin receptor substrate 1 MGI:99454 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Increased LDL cholesterol concentration |
Hypercholesterolemia |
Hypertriglyceridemia |
Glucose intolerance |
Diabetes mellitus |
Type II diabetes mellitus |
Impaired glucose tolerance |
Insulin resistance |
Disease(s) Associated with IRS1 | ||||||||
coronary artery disease | ||||||||
type 2 diabetes mellitus |
Mouse Phenotypes | homeostasis/metabolism phenotype |
abnormal vascular wound healing |
decreased insulin secretion |
decreased circulating glucose level |
increased circulating insulin level |
decreased circulating HDL cholesterol level |
increased circulating free fatty acids level |
increased circulating triglyceride level |
abnormal glucose homeostasis |
impaired glucose tolerance |
insulin resistance |
abnormal lipid level |
impaired lipolysis |
abnormal bone healing |
|
Availability | Mouse Genotype | ||||||||||||||
Irs1m1Btlr/Irs1m1Btlr | |||||||||||||||
Irs1Sml/Irs1Sml | |||||||||||||||
Irs1tm1Jos/Irs1tm1Jos | |||||||||||||||
Irs1tm1Tka/Irs1tm1Tka | * | ||||||||||||||
Irs1tm2.1Mfw/Irs1tm2.1Mfw | |||||||||||||||
Irs1Sml/Irs1+ | |||||||||||||||
Irs1tm2.1Mfw/Irs1+ | |||||||||||||||
Irs1tm1Mfw/Irs1tm1Mfw Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
|||||||||||||||
Irs1tm2Tka/Irs1tm2Tka Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
* |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/02/2024 MGI 6.24 |
|
|