Symbol Name ID |
Was
Wiskott-Aldrich syndrome MGI:105059 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Reduced natural killer cell activity |
Increased circulating IgA concentration |
Increased circulating IgE concentration |
Decreased circulating total IgM |
Decreased specific anti-polysaccharide antibody level |
Abnormal delayed hypersensitivity skin test |
Autoimmune hemolytic anemia |
Eosinophilia |
Neutropenia |
Decreased CD4:CD8 ratio |
Decreased proportion of CD4-positive helper T cells |
Decreased proportion of CD8-positive T cells |
Lymphopenia |
Monocytopenia |
Leukocytosis |
Absent microvilli on the surface of peripheral blood lymphocytes |
Impaired lymphocyte transformation with phytohemagglutinin |
Recurrent sinusitis |
Recurrent upper respiratory tract infections |
Splenomegaly |
Inflammation of the large intestine |
Ulcerative colitis |
Recurrent otitis media |
Eczematoid dermatitis |
Recurrent pneumonia |
Reduced lymphocyte surface expression of CD43 |
Sepsis |
Recurrent bacterial infections |
Recurrent lower respiratory tract infections |
Recurrent meningitis |
Recurrent herpes |
Disease(s) Associated with WAS | |||||||||||||||||||||||||||||||
thrombocytopenia | |||||||||||||||||||||||||||||||
Wiskott-Aldrich syndrome | |||||||||||||||||||||||||||||||
X-linked severe congenital neutropenia |
Mouse Phenotypes | immune system phenotype |
abnormal osteoclast differentiation |
abnormal B cell proliferation |
decreased T cell proliferation |
colitis |
thymus hypoplasia |
abnormal thymocyte activation |
spleen hyperplasia |
abnormal double-negative T cell morphology |
abnormal double-positive T cell morphology |
decreased double-positive T cell number |
increased neutrophil cell number |
abnormal mast cell morphology |
abnormal B cell number |
increased germinal center B cell number |
decreased mature B cell number |
decreased follicular B cell number |
decreased marginal zone B cell number |
increased follicular B cell number |
increased plasma cell number |
decreased B cell number |
increased B cell number |
decreased NK cell number |
decreased T cell number |
decreased lymphocyte cell number |
increased monocyte cell number |
increased leukocyte cell number |
abnormal dendritic cell morphology |
abnormal lymphocyte morphology |
increased splenocyte number |
abnormal mast cell physiology |
abnormal B cell physiology |
increased IgA level |
increased IgE level |
increased IgM level |
abnormal osteoclast physiology |
lymphoid hypoplasia |
abnormal dendritic cell physiology |
abnormal dendritic cell antigen presentation |
abnormal cytokine secretion |
increased autoantibody level |
increased anti-chromatin antibody level |
increased anti-double stranded DNA antibody level |
increased anti-single stranded DNA antibody level |
glomerulonephritis |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||
Wastm1Itl/Wastm1Itl | ||||||||||||||||||||||||||||||||||||||||||||||
Wastm1Kas/Wastm1Kas | ||||||||||||||||||||||||||||||||||||||||||||||
Wastm1Sbs/Wastm1Sbs | * | |||||||||||||||||||||||||||||||||||||||||||||
Wastm2Itl/Wastm2Itl | ||||||||||||||||||||||||||||||||||||||||||||||
Wastm1Itl/Y | ||||||||||||||||||||||||||||||||||||||||||||||
Wastm1Sbs/Y | ||||||||||||||||||||||||||||||||||||||||||||||
Wastm2Itl/Y | ||||||||||||||||||||||||||||||||||||||||||||||
Cd79atm1(cre)Reth/Cd79a+ Wastm1.1Ldn/Wastm1.1Ldn (conditional) |
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Cd79atm1(cre)Reth/Cd79a+ Wastm1.1Ldn/Y (conditional) |
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Cd79atm1(cre)Reth/Cd79a+ Wastm1.1Ldn/Was+ (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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