Symbol
Name
ID

Mapkapk2
MAP kinase-activated protein kinase 2
MGI:109298

Phenotype annotations related to immune system

Darker colors indicate more annotations

Mouse Phenotypes

abnormal macrophage derived foam cell morphology

impaired macrophage phagocytosis

increased eosinophil cell number

increased large unstained cell number

increased leukocyte cell number

increased spleen germinal center size

decreased circulating tumor necrosis factor level

abnormal cytokine level

abnormal cytokine secretion

decreased interferon-gamma secretion

increased interleukin-1 beta secretion

decreased tumor necrosis factor secretion

decreased susceptibility to endotoxin shock

increased susceptibility to bacterial infection

increased susceptibility to bacterial infection induced morbidity/mortality

Availability

Mouse Genotype

Mapkapk2^tm1.2Gkl/Mapkapk2^tm1.2Gkl

Mapkapk2^{tm1b(EUCOMM)Hmgu}/Mapkapk2^{tm1b(EUCOMM)Hmgu}

Mapkapk2^tm1Mgl/Mapkapk2^tm1Mgl

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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