Symbol Name ID |
Irf4
interferon regulatory factor 4 MGI:1096873 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Increased circulating IgA concentration |
Increased circulating IgG concentration |
Decreased circulating antibody concentration |
Paraproteinemia |
Acute lymphoblastic leukemia |
T-cell acute lymphoblastic leukemias |
Chronic lymphatic leukemia |
Lymphadenopathy |
Splenomegaly |
Cellular immunodeficiency |
Disease(s) Associated with IRF4 | ||||||||||
acute lymphoblastic leukemia | ||||||||||
chronic lymphocytic leukemia | ||||||||||
multiple myeloma |
Mouse Phenotypes | immune system phenotype |
decreased B cell proliferation |
decreased T cell proliferation |
abnormal thymus morphology |
enlarged thymus |
enlarged spleen |
increased spleen weight |
abnormal B cell differentiation |
abnormal class switch recombination |
arrested B cell differentiation |
abnormal T-helper 1 cell differentiation |
increased neutrophil cell number |
decreased plasmacytoid dendritic cell number |
decreased dendritic cell number |
absent plasma cells |
decreased lymphocyte cell number |
increased lymphocyte cell number |
abnormal memory B cell morphology |
abnormal CD4-positive, alpha beta T cell morphology |
abnormal spleen morphology |
absent spleen germinal center |
abnormal B cell physiology |
abnormal B cell activation |
decreased IgG1 level |
decreased IgG level |
decreased IgM level |
decreased immunoglobulin level |
abnormal immune system cell morphology |
abnormal lymph node morphology |
absent lymph node germinal center |
enlarged lymph nodes |
abnormal immune system physiology |
increased susceptibility to bacterial infection |
increased susceptibility to Riboviria infection |
|
Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||
Irf4em1(IMPC)Mbp/Irf4em1(IMPC)Mbp | |||||||||||||||||||||||||||||||||||
Irf4m1Btlr/Irf4m1Btlr | * | ||||||||||||||||||||||||||||||||||
Irf4M2Btlr/Irf4M2Btlr | |||||||||||||||||||||||||||||||||||
Irf4tm1.1Rdf/Irf4tm1.1Rdf | |||||||||||||||||||||||||||||||||||
Irf4tm1Mak/Irf4tm1Mak | * | ||||||||||||||||||||||||||||||||||
Irf4M2Btlr/Irf4+ | |||||||||||||||||||||||||||||||||||
Irf4tm1Rdf/Irf4tm1.1Rdf | * | ||||||||||||||||||||||||||||||||||
Ighg1tm1(cre)Cgn/Ighg1+ Irf4tm1Rdf/Irf4tm1.1Rdf (conditional) |
* |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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