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Symbol
Name
ID 		Irf4
interferon regulatory factor 4
MGI:1096873
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgA concentration
Increased circulating IgG concentration
Decreased circulating antibody concentration
Paraproteinemia
Acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemias
Chronic lymphatic leukemia
Lymphadenopathy
Splenomegaly
Cellular immunodeficiency
Disease(s) Associated with IRF4
acute lymphoblastic leukemia
chronic lymphocytic leukemia
multiple myeloma

Mouse Phenotypes
immune system phenotype
decreased B cell proliferation
decreased T cell proliferation
abnormal thymus morphology
enlarged thymus
enlarged spleen
increased spleen weight
abnormal B cell differentiation
abnormal class switch recombination
arrested B cell differentiation
abnormal T-helper 1 cell differentiation
increased neutrophil cell number
decreased plasmacytoid dendritic cell number
decreased dendritic cell number
absent plasma cells
decreased lymphocyte cell number
increased lymphocyte cell number
abnormal memory B cell morphology
abnormal CD4-positive, alpha beta T cell morphology
abnormal spleen morphology
absent spleen germinal center
abnormal B cell physiology
abnormal B cell activation
decreased IgG1 level
decreased IgG level
decreased IgM level
decreased immunoglobulin level
abnormal immune system cell morphology
abnormal lymph node morphology
absent lymph node germinal center
enlarged lymph nodes
abnormal immune system physiology
increased susceptibility to bacterial infection
increased susceptibility to Riboviria infection
Availability Mouse Genotype
Irf4em1(IMPC)Mbp/Irf4em1(IMPC)Mbp
Irf4m1Btlr/Irf4m1Btlr *
Irf4M2Btlr/Irf4M2Btlr
Irf4tm1.1Rdf/Irf4tm1.1Rdf
Irf4tm1Mak/Irf4tm1Mak *
Irf4M2Btlr/Irf4+
Irf4tm1Rdf/Irf4tm1.1Rdf *
Ighg1tm1(cre)Cgn/Ighg1+
Irf4tm1Rdf/Irf4tm1.1Rdf  (conditional)		 *
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory