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Symbol
Name
ID
Npc1
NPC intracellular cholesterol transporter 1
MGI:1097712
Phenotype annotations related to immune system
Darker colors indicate more annotations

Mouse Phenotypes
increased macrophage derived foam cell number
enlarged spleen
increased macrophage cell number
abnormal macrophage morphology
abnormal alveolar macrophage morphology
microgliosis
abnormal microglial cell activation
increased microglial cell activation
nasal inflammation
Availability Mouse Genotype
Npc1m1N/Npc1m1N
Npc1nmf164/Npc1nmf164
Npc1spm/Npc1spm
Npc1tm1.1Dso/Npc1tm1.1Dso
Npc1m1N/Npc1tm1.2Apl
Npc1m1N/Npc1tm1.1Apl
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)
Npc1m1N/Npc1tm1.1Apl
Tg(Syn1-cre)671Jxm/0  (conditional)
Npc1tm1.1Apl/Npc1tm1.2Apl
Tg(Pcp2-cre)2Mpin/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory