Symbol Name ID |
Ikbkg
inhibitor of kappaB kinase gamma MGI:1338074 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Reduced natural killer cell activity |
Increased circulating IgA level |
Abnormal circulating IgG level |
Decreased circulating total IgM |
Increased circulating IgM level |
Dysgammaglobulinemia |
Eosinophilia |
Leukocytosis |
Keratitis |
Uveitis |
Iridocyclitis |
Epididymitis |
Erythema nodosum |
Maculopapular exanthema |
Immunodeficiency |
Disseminated nontuberculous mycobacterial infection |
Pneumocystis jirovecii pneumonia |
Recurrent bacterial infections |
Severe cytomegalovirus infection |
Molluscum contagiosum |
Disease(s) Associated with IKBKG | ||||||||||||||||||||
Behcet's disease | ||||||||||||||||||||
Bloch-Sulzberger syndrome | ||||||||||||||||||||
ectodermal dysplasia and immunodeficiency 1 | ||||||||||||||||||||
immunodeficiency 33 |
Mouse Phenotypes | immune system phenotype |
increased T cell apoptosis |
increased B cell proliferation |
colitis |
small thymus |
enlarged spleen |
abnormal B cell differentiation |
decreased immature B cell number |
decreased mature B cell number |
decreased B-1 B cell number |
decreased follicular B cell number |
decreased marginal zone B cell number |
decreased B cell number |
decreased NK cell number |
decreased CD4-positive, alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
decreased NK T cell number |
decreased regulatory T cell number |
decreased T cell number |
decreased single-positive T cell number |
small spleen |
abnormal NK cell physiology |
abnormal NK T cell physiology |
increased circulating tumor necrosis factor level |
abnormal humoral immune response |
abnormal cytokine secretion |
abnormal chemokine secretion |
increased interferon-gamma secretion |
decreased interleukin-12b secretion |
decreased interleukin-6 secretion |
increased interleukin-6 secretion |
decreased tumor necrosis factor secretion |
abnormal inflammatory response |
decreased susceptibility to endotoxin shock |
increased susceptibility to endotoxin shock |
liver inflammation |
skin inflammation |
erythroderma |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||
Ikbkgtm1Dwb/Ikbkgtm1Dwb | |||||||||||||||||||||||||||||||||||||||
Ikbkgtm1.1Dwat/Ikbkg+ | |||||||||||||||||||||||||||||||||||||||
Ikbkgtm1Mka/Ikbkg+ | |||||||||||||||||||||||||||||||||||||||
Ikbkgtm1Mpa/Ikbkg+ | |||||||||||||||||||||||||||||||||||||||
Ikbkgm1Btlr/Y | * | ||||||||||||||||||||||||||||||||||||||
Ikbkgtm1Mak/Y | |||||||||||||||||||||||||||||||||||||||
Ikbkgtm1Mpa/Y | |||||||||||||||||||||||||||||||||||||||
Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr Tg(Alb1-cre)7Gsc/0 (conditional) |
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Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa Cd79atm1(cre)Reth/Cd79a+ (conditional) |
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Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa Tg(Alb1-cre)7Gsc/0 (conditional) |
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Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa Tg(Vil1-cre)997Gum/0 (conditional) |
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Cd19tm1(cre)Cgn/Cd19+ Ikbkgtm1.1Mpa/Y (conditional) |
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Ikbkgtm1.1Chtr/Y Tg(Alb1-cre)7Gsc/0 (conditional) |
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Ikbkgtm1.1Mpa/Y Tg(Cd4-cre)1Cwi/0 (conditional) |
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Ikbkgtm1.1Mpa/Y Tg(Vil1-cre)997Gum/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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