|
Symbol Name ID |
Tlr2
toll-like receptor 2 MGI:1346060 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Allergic rhinitis |
Conjunctivitis |
Abnormality of the spleen |
Subacute progressive viral hepatitis |
Uveitis |
Iridocyclitis |
Epididymitis |
Eczematoid dermatitis |
Atopic dermatitis |
Erythema nodosum |
Recurrent skin infections |
Autoimmunity |
Asthma |
| Disease(s) Associated with TLR2 | |||||||||||||
| asthma | |||||||||||||
| atopic dermatitis | |||||||||||||
| Behcet's disease | |||||||||||||
| hepatocellular carcinoma | |||||||||||||
| leprosy | |||||||||||||
| type 1 diabetes mellitus |
| Mouse Phenotypes | immune system phenotype |
increased B cell apoptosis |
abnormal leukocyte migration |
abnormal cellular extravasation |
decreased splenocyte proliferation |
increased susceptibility to induced colitis |
insulitis |
increased T cell number |
decreased immunoglobulin level |
abnormal macrophage physiology |
decreased macrophage cytokine production |
decreased macrophage nitric oxide production |
decreased microglial cell activation |
abnormal osteoclast physiology |
decreased circulating interleukin-1 beta level |
decreased circulating tumor necrosis factor level |
abnormal chemokine level |
abnormal interleukin level |
abnormal tumor necrosis factor level |
abnormal dendritic cell physiology |
abnormal cytokine secretion |
abnormal interleukin secretion |
decreased interleukin-1 beta secretion |
decreased interleukin-1 secretion |
decreased interleukin-10 secretion |
decreased interleukin-12 secretion |
decreased interleukin-12b secretion |
decreased interleukin-6 secretion |
decreased tumor necrosis factor secretion |
decreased inflammatory response |
abnormal innate immunity |
decreased susceptibility to bacterial infection induced morbidity/mortality |
increased susceptibility to bacterial infection |
increased susceptibility to bacterial infection induced morbidity/mortality |
decreased susceptibility to Herpesvirales infection induced morbidity/mortality |
decreased susceptibility to parasitic infection |
decreased susceptibility to Herpesvirales infection |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||
| Tlr2lngd/Tlr2lngd | ||||||||||||||||||||||||||||||||||||||
| Tlr2tm1Aki/Tlr2tm1Aki | * | |||||||||||||||||||||||||||||||||||||
| Tlr2tm1Kir/Tlr2tm1Kir | ||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/02/2024 MGI 6.24 |
|
|
|
||
Analysis Tools