Symbol Name ID |
Rab27a
RAB27A, member RAS oncogene family MGI:1861441 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Reduced delayed hypersensitivity |
Neutropenia |
Hemophagocytosis |
Lymphadenopathy |
Splenomegaly |
Hepatosplenomegaly |
Immunodeficiency |
Recurrent bacterial infections |
Disease(s) Associated with RAB27A | ||||||||
Griscelli syndrome type 2 |
Mouse Phenotypes | immune system phenotype |
abnormal NK cell degranulation |
decreased NK cell degranulation |
decreased neutrophil cell number |
decreased leukocyte cell number |
abnormal neutrophil physiology |
impaired natural killer cell mediated cytotoxicity |
abnormal cytotoxic T cell physiology |
decreased cytotoxic T cell cytolysis |
increased circulating interferon-gamma level |
increased circulating interleukin-1 beta level |
increased circulating interleukin-6 level |
increased circulating tumor necrosis factor level |
increased susceptibility to Riboviria infection |
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Availability | Mouse Genotype | ||||||||||||||
Rab27aash/Rab27aash | * | ||||||||||||||
Rab27acct/Rab27acct | * |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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