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Symbol
Name
ID

Rnf128
ring finger protein 128
MGI:1914139

Phenotype annotations related to immune system

Darker colors indicate more annotations

Mouse Phenotypes

increased T cell proliferation

increased splenocyte proliferation

enlarged spleen

increased effector memory T-helper cell number

increased IgG1 level

increased IgM level

abnormal CD4-positive, alpha-beta T cell physiology

abnormal regulatory T cell physiology

abnormal macrophage physiology

increased circulating interleukin-2 level

enlarged mesenteric lymph nodes

increased interferon-gamma secretion

abnormal interleukin secretion

decreased interleukin-13 secretion

increased interleukin-17 secretion

increased interleukin-2 secretion

increased interleukin-21 secretion

decreased interleukin-4 secretion

increased interleukin-4 secretion

decreased interleukin-5 secretion

abnormal immune tolerance

abnormal peripheral T cell anergy

increased susceptibility to experimental autoimmune encephalomyelitis

increased anti-double stranded DNA antibody level

CNS inflammation

lung inflammation

Availability

Mouse Genotype

Rnf128^tm1.1Flv/Rnf128^tm1.1Flv

Rnf128^tm1.2Cmse/Rnf128^tm1.2Cmse

Rnf128^tm1Cdon/Rnf128^tm1Cdon

Rnf128^tm1Cdon/Rnf128⁺

Rnf128^{tm1.1(KOMP)Vlcg}/Y

Rnf128^tm1.1Flv/Y

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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