Symbol Name ID |
Dock8
dedicator of cytokinesis 8 MGI:1921396 |
Darker colors indicate more annotations |
Human Phenotypes | Increased circulating IgE level |
Autoimmune hemolytic anemia |
Neutropenia |
Neutropenia in presence of anti-neutropil antibodies |
B lymphocytopenia |
Reduced proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells |
T lymphocytopenia |
Autoimmune thrombocytopenia |
Recurrent sinusitis |
Lymphadenopathy |
Splenomegaly |
Colitis |
Recurrent gastroenteritis |
Hepatitis |
Chronic otitis media |
Thyroiditis |
Membranous nephropathy |
Inflammatory abnormality of the skin |
Crusting erythematous dermatitis |
Eczematoid dermatitis |
Atopic dermatitis |
Psoriasiform dermatitis |
Recurrent skin infections |
Recurrent bacterial skin infections |
Myositis |
Osteomyelitis |
Pneumonia |
Autoimmunity |
Anti-liver cytosolic antigen type 1 antibody positivity |
Anti-thyroid peroxidase antibody positivity |
Insulin receptor antibody positivity |
Allergy |
Asthma |
Sepsis |
Recurrent infections |
Onychomycosis |
Recurrent candida infections |
Recurrent respiratory infections |
Recurrent viral infections |
Meningitis |
Disease(s) Associated with DOCK8 | ||||||||||||||||||||||||||||||||||||||||
hyper IgE recurrent infection syndrome 2 | ||||||||||||||||||||||||||||||||||||||||
immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome |
Mouse Phenotypes | abnormal cellular extravasation |
decreased T cell proliferation |
abnormal B cell differentiation |
abnormal T cell differentiation |
abnormal CD4-positive T cell differentiation |
abnormal CD8-positive, alpha-beta T cell differentiation |
decreased germinal center B cell number |
decreased B-1 B cell number |
decreased marginal zone B cell number |
absent marginal zone B cells |
increased central memory CD4-positive, alpha-beta T cell number |
increased effector memory CD4-positive, alpha-beta T cell number |
decreased CD4-positive, alpha-beta T cell number |
increased CD4-positive, alpha-beta T cell number |
increased central memory CD8 positive, alpha-beta T cell number |
increased effector memory CD8-positive, alpha-beta T cell number |
decreased CD8-positive, naive alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
decreased T cell number |
decreased activated T cell number |
decreased spleen germinal center size |
decreased IgG level |
decreased IgM level |
decreased follicular dendritic cell number |
abnormal dendritic cell physiology |
abnormal humoral immune response |
impaired humoral immune response |
decreased susceptibility to experimental autoimmune encephalomyelitis |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||
Dock8cpm/Dock8cpm | |||||||||||||||||||||||||||||
Dock8m1Anu/Dock8m1Anu | |||||||||||||||||||||||||||||
Dock8m1Btlr/Dock8m1Btlr | |||||||||||||||||||||||||||||
Dock8m2Anu/Dock8m2Anu | |||||||||||||||||||||||||||||
Dock8M2Btlr/Dock8M2Btlr | |||||||||||||||||||||||||||||
Dock8M3Btlr/Dock8M3Btlr | |||||||||||||||||||||||||||||
Dock8m4Btlr/Dock8m4Btlr | |||||||||||||||||||||||||||||
Dock8pri/Dock8pri | |||||||||||||||||||||||||||||
Dock8tm1Ysfk/Dock8tm1Ysfk | |||||||||||||||||||||||||||||
Dock8cpm/Dock8pri |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/02/2024 MGI 6.13 |
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