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Symbol
Name
ID

Mtor
mechanistic target of rapamycin kinase
MGI:1928394

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Pyelonephritis	Recurrent urinary tract infections
Disease(s) Associated with MTOR	Pyelonephritis	Recurrent urinary tract infections
autosomal dominant polycystic kidney disease

Mouse Phenotypes

immune system phenotype

decreased splenocyte apoptosis

impaired B cell migration

decreased B cell proliferation

decreased T cell proliferation

decreased splenocyte proliferation

abnormal thymus cell ratio

decreased thymocyte number

decreased transitional stage T1 B cell number

abnormal T cell differentiation

decreased double-positive T cell number

decreased neutrophil cell number

decreased follicular B cell number

decreased marginal zone B cell number

decreased plasma cell number

decreased B cell number

abnormal T cell subpopulation ratio

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

increased regulatory T cell number

decreased monocyte cell number

abnormal T cell morphology

small spleen

decreased splenocyte number

abnormal B cell physiology

decreased IgG level

decreased IgM level

abnormal T cell physiology

abnormal humoral immune response

decreased interferon-gamma secretion

decreased interleukin-17 secretion

decreased interleukin-2 secretion

decreased tumor necrosis factor secretion

Availability

Mouse Genotype

Mtor^chino/Mtor^chino

*

Mtor^tm1.1Lgm/Mtor^tm1.1Lgm

*

Mtor^tm1Lgm/Mtor^tm1Lgm

Mtor^tm1.2Koz/Mtor^tm1.2Koz
Tg(Cd4-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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