Symbol
Name
ID

Stk4
serine/threonine kinase 4
MGI:1929004

Phenotype annotations related to immune system

Darker colors indicate more annotations

Mouse Phenotypes

increased T cell apoptosis

abnormal leukocyte migration

abnormal leukocyte adhesion

increased T cell proliferation

thymus hyperplasia

increased thymocyte number

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

increased neutrophil cell number

decreased CD11b-high dendritic cell number

decreased myeloid dendritic cell number

increased dendritic cell number

decreased B-1 B cell number

decreased B-2 B cell number

decreased marginal zone B cell number

increased B-1b cell number

decreased B cell number

increased NK cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

abnormal memory T cell number

decreased T cell number

decreased single-positive T cell number

increased single-positive T cell number

decreased lymphocyte cell number

increased macrophage cell number

abnormal marginal zone B cell morphology

abnormal spleen B cell follicle morphology

decreased spleen B cell follicle size

decreased spleen white pulp amount

abnormal B cell physiology

decreased IgD level

increased IgE level

decreased IgG level

increased IgM level

abnormal T cell physiology

abnormal CD4-positive, alpha-beta T cell physiology

abnormal CD8-positive, alpha-beta T cell physiology

abnormal immune system organ morphology

abnormal Peyer's patch T cell area morphology

abnormal Peyer's patch germinal center morphology

abnormal dendritic cell physiology

abnormal humoral immune response

impaired humoral immune response

increased interferon-gamma secretion

increased interleukin-2 secretion

increased interleukin-4 secretion

Availability

Mouse Genotype

Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}

Stk4^m1Btlr/Stk4^m1Btlr

Stk4^m2Btlr/Stk4^m2Btlr

Stk4^m3Btlr/Stk4^m3Btlr

Stk4^m4Btlr/Stk4^m4Btlr

Stk4^m5Btlr/Stk4^m5Btlr

Stk4^tm1.1Kina/Stk4^tm1.1Kina

Stk4^tm1.2Wtao/Stk4^tm1.2Wtao

Stk4^tm1Dlim/Stk4^tm1Dlim

Stk4^tm1.1Wtao/Stk4^tm1.2Wtao
Tg(Lck-cre)#Zhu/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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