Symbol Name ID |
Bcl11b
B cell leukemia/lymphoma 11B MGI:1929913 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Eosinophilia |
Decreased proportion of naive CD4 T cells |
Abnormally low T cell receptor excision circle level |
T lymphocytopenia |
Lymphopenia |
Impaired lymphocyte transformation with phytohemagglutinin |
Psoriasiform dermatitis |
Severe combined immunodeficiency |
Disease(s) Associated with BCL11B | ||||||||
immunodeficiency 49 |
Mouse Phenotypes | immune system phenotype |
increased thymocyte apoptosis |
abnormal thymus cortex morphology |
absent thymus corticomedullary boundary |
abnormal thymus medulla morphology |
thymus hypoplasia |
decreased thymocyte number |
abnormal thymocyte activation |
increased spleen weight |
spleen hyperplasia |
abnormal NK cell differentiation |
abnormal T cell differentiation |
abnormal T cell receptor beta chain V(D)J recombination |
abnormal positive T cell selection |
decreased double-negative T cell number |
increased double-negative T cell number |
decreased double-positive T cell number |
increased dendritic cell number |
increased B cell number |
increased NK cell number |
abnormal T cell number |
decreased CD4-positive, alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
increased gamma-delta T cell number |
absent T cells |
abnormal leukocyte morphology |
abnormal T cell morphology |
enlarged mesenteric lymph nodes |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||
Bcl11btm1.2Leid/Bcl11btm1.2Leid | ||||||||||||||||||||||||||||||
Bcl11btm1Jpk/Bcl11btm1Jpk | ||||||||||||||||||||||||||||||
Bcl11btm1Avram/Bcl11btm1Avram Tg(Cd4-cre)1Cwi/? (conditional) |
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Bcl11btm1Peli/Bcl11btm1Peli Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ (conditional) |
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Bcl11btm2.1Jpk/Bcl11b+ Tg(Cd4-cre)1Cwi/0 (conditional) |
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Bcl11btm2.1Jpk/Bcl11b+ Tg(Lck-cre)1Jtak/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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